Evidence map›Paper›PMID 34862221›Full record

ArticleClinical medicine (London, England)2021

Increased frequency of pneumothorax and pneumomediastinum in COVID-19 patients admitted in the ICU: A multicentre study from Mumbai, India.

Zarir F Udwadia, Kedar K Toraskar, Lancelot Pinto, Jai Mullerpatan, Haresh D Wagh, Joanne M Mascarenhas, Bhavesh M Gandhi, Awatansh Tripathi, Ayesha Sunavala, Umang Agrawal and 7 more

Abstract readMulticenter Study
In one paragraph

Article in Clinical medicine (London, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Observational
  3. Article
  4. Article
  5. Article
  6. Air leaks in COVID-19.World journal of virology · 2022
    Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Zarir F UdwadiaPD Hinduja National Hospital & Medical Research Centre, Mumbai, India zfu@hindujahospital.com.
Kedar K ToraskarWockhardt Hospital, Mumbai, India.
Lancelot PintoPD Hinduja National Hospital & Medical Research Centre, Mumbai, India.
Jai MullerpatanPD Hinduja National Hospital & Medical Research Centre, Mumbai, India.
Haresh D WaghPD Hinduja National Hospital & Medical Research Centre, Mumbai, India.
Joanne M MascarenhasBreach Candy Hospital Trust, Mumbai, India.
Bhavesh M GandhiBreach Candy Hospital Trust, Mumbai, India.
Awatansh TripathiPD Hinduja National Hospital & Medical Research Centre, Mumbai, India.
Ayesha SunavalaPD Hinduja National Hospital & Medical Research Centre, Mumbai, India.
Umang AgrawalPD Hinduja National Hospital & Medical Research Centre, Mumbai, India.
Viral NandaPD Hinduja National Hospital & Medical Research Centre, Mumbai, India.
Nikita AbrahamPD Hinduja National Hospital & Medical Research Centre, Mumbai, India.
Bony FrancisPD Hinduja National Hospital & Medical Research Centre, Mumbai, India.
Ravindra R ZoreWockhardt Hospital, Mumbai, India.
Gurudas PundpalWockhardt Hospital, Mumbai, India.
Bhoosan GondseWockhardt Hospital, Mumbai, India.
Gaurav A GuptaWockhardt Hospital, Mumbai, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere are limited data regarding the incidence of pneumothorax in COVID-19 patients as well as the impact of the same on patient outcomes.

methodsA retrospective review of the medical records at three large tertiary care hospitals in Mumbai was performed to identify patients hospitalised with COVID-19 from March 2020 to October 2020. The presence of pneumothorax and/or pneumomediastinum was noted when chest radiographs or CT scans were performed. Demographic and clinical characteristics of patients who developed air leak were recorded.

results4,906 patients with COVID-19 were admitted, with 1,324 (27%) having severe COVID-19 disease. The overall incidence of pneumothorax and/or pneumomediastinum in patients with severe disease was 3.2% (42/1,324). Eighteen patients had pneumothorax, 16 had pneumomediastinum and 8 patients had both. Fourteen patients (33.3%) developed this complication breathing spontaneously, 28 patients (66.6%) developed it during mechanical ventilation. Overall mortality in this cohort was 74%, compared with 17% in the COVID-19 patients without pneumothorax (p<0.001).

conclusionsOur study demonstrates that air leaks occur with a higher frequency in patients with COVID-19 than in other ICU patients. When present, such air leaks contributed to poor outcomes with almost 74% mortality rates in these patients.

Indexed as

COVID-19Mediastinal EmphysemaPneumothoraxHumansIntensive Care UnitsRetrospective StudiesSARS-CoV-2air leak in COVID-19barotrauma in COVID-19pneumomediastinumpneumothorax

Identifiers

PMID34862221
PMCPMC8806291

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.