Evidence map›Paper›PMID 34862187›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2022

Chemical Signaling Regulates Axon Regeneration via the GPCR-Gqα Pathway in

Tatsuhiro Shimizu, Kayoko Sugiura, Yoshiki Sakai, Abdul R Dar, Rebecca A Butcher, Kunihiro Matsumoto, Naoki Hisamoto

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. GPCR Sense Communication Among Interaction Nematodes with Other Organisms.International journal of molecular sciences · 2025
    Review
  2. Article
  3. Nematode Pheromones: Structures and Functions.Molecules (Basel, Switzerland) · 2023
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Tatsuhiro ShimizuDivision of Biological Science, Graduate School of Science, Nagoya University, Nagoya 464-8602, Japan.
Kayoko SugiuraDivision of Biological Science, Graduate School of Science, Nagoya University, Nagoya 464-8602, Japan.
Yoshiki SakaiDivision of Biological Science, Graduate School of Science, Nagoya University, Nagoya 464-8602, Japan.
Abdul R DarDepartment of Chemistry, University of Florida, Gainesville, Florida 32603.
Rebecca A ButcherDepartment of Chemistry, University of Florida, Gainesville, Florida 32603.
Kunihiro MatsumotoDivision of Biological Science, Graduate School of Science, Nagoya University, Nagoya 464-8602, Japan g44177a@nucc.cc.nagoya-u.ac.jp i45556a@cc.nagoya-u.ac.jp.
Naoki HisamotoDivision of Biological Science, Graduate School of Science, Nagoya University, Nagoya 464-8602, Japan g44177a@nucc.cc.nagoya-u.ac.jp i45556a@cc.nagoya-u.ac.jp.
Nagoya University · JPUniversity of Florida · US

Funding

Small-molecule signals controlling nematode developmentR01GM118775 · NIGMS · UNIVERSITY OF FLORIDA · PI BUTCHER, REBECCA A · 2016 to 2020
$1.2M
NIGMS NIH HHS R01 GM118775
6 · The paper itself

Abstract

Chemical communication controls a wide range of behaviors via conserved signaling networks. Axon regeneration in response to injury is determined by the interaction between the extracellular environment and intrinsic growth potential. In this study, we investigated the role of chemical signaling in axon regeneration in

Indexed as

AnimalsAnimals, Genetically ModifiedAxonsCaenorhabditis elegansCaenorhabditis elegans ProteinsGTP-Binding Protein alpha Subunits, Gq-G11Nerve RegenerationReceptors, G-Protein-CoupledSignal TransductionCaenorhabditis elegans ProteinsGTP-Binding Protein alpha Subunits, Gq-G11Receptors, G-Protein-Coupledaxon regenerationC. eleganschemical signaling

Identifiers

PMID34862187
PMCPMC8808735
OpenAlexW3215024040

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.