Evidence map›Paper›PMID 34861995›Full record

ReviewSeminars in radiation oncology2022

Translation of Precision Medicine Research Into Biomarker-Informed Care in Radiation Oncology.

Jessica A Scarborough, Jacob G Scott

Open access · greenAbstract readReview
In one paragraph

Review in Seminars in radiation oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Observational
  2. Personalization of Radiotherapy Dose in HPV Positive Oropharynx Cancer Using GARD.medRxiv : the preprint server for health sciences · 2025
    Article
  3. Gene Signatures and Oncology Treatment Implications.Hematology/oncology clinics of North America · 2025
    Review
  4. Review
  5. Cross fertilisation of Public Health and Translational Research.Journal of the Indian Institute of Science · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Jessica A ScarboroughTranslational Hematology and Oncology Research Department, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland,OH; Systems Biology and Bioinformatics Program, School of Medicine, Case Western Reserve University, Cleveland, OH.
Jacob G ScottTranslational Hematology and Oncology Research Department, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland,OH; Radiation Oncology Department, Taussig Cancer Institute, Cleveland Clinic Foundation, 10201 Carnegie Ave, Cleveland, OH. Electronic address: scottj10@ccf.org.
Cleveland Clinic · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007250 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI HUANG, ALEX YEE-CHEN · 1985 to 2023
$33.4M
TRANSLATIONAL RESEARCH ONCOLOGY TRAINING GRANTK12CA076917 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI GERSON, STANTON L. · 1997 to 2022
$14.2M
Translational and Clinical Trial Correlates CoreU54CA274513 · NCI · CLEVELAND CLINIC LERNER COM-CWRU · PI Timothy An-thy Chan, David Sung-wen Yu · 2022 to 2026
$9.3M
Exploiting Ecology and Evolution to Prevent Therapy Resistance in EGFR-Driven Lung CancerR37CA244613 · NCI · CLEVELAND CLINIC LERNER COM-CWRU · PI Jacob Gardinier Scott · 2020 to 2026
$4.0M
Exploiting convergent evolution to design biomarker extraction tools for the prediction of therapeutic response in cancerF30CA257076 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI SCARBOROUGH, JESSICA ANNE · 2021 to 2024
$209k
NCI NIH HHS F30 CA257076NCI NIH HHS K12 CA076917NCI NIH HHS R37 CA244613NCI NIH HHS U54 CA274513NIGMS NIH HHS T32 GM007250
6 · The paper itself

Abstract

The reach of personalized medicine in radiation oncology has expanded greatly over the past few decades as technical precision has improved the delivery of radiation to each patient's unique anatomy. Yet, the consideration of biological heterogeneity between patients has largely not been translated to clinical care. There are innumerable promising advancements in the discovery and validation of biomarkers, which could be used to alter radiation therapy directly or indirectly. Directly, biomarker-informed care may alter treatment dose or identify patients who would benefit most from radiation therapy and who could safely avoid more aggressive care. Indirectly, a variety of biomarkers could assist with choosing the best radiosensitizing chemotherapies. The translation of these advancements into clinical practice will bring radiation oncology even further into the era of precision medicine, treating patients according to their unique anatomical and biological differences.

Indexed as

NeoplasmsRadiation OncologyBiomarkersHumansPrecision MedicineBiomarkersBiomarkersGenomicsPrecision medicineRadiotherapy response predictionTranscriptomics

Identifiers

PMID34861995
PMCPMC8667861
OpenAlexW3215769388

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.