ArticleBMC gastroenterology2021
Detection and characterization of human astrovirus and sapovirus in outpatients with acute gastroenteritis in Guangzhou, China.
Article in BMC gastroenterology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 27 citations in OpenAlex.
- Epidemiological and Genotypic Trends of Enteric Adenovirus, Astrovirus, and Sapovirus in Gwangju, Korea, 2017-2023.Journal of Korean medical science · 2026Article
- Epidemiology and Clinical Impact of Pediatric Viral Gastroenteritis Before and After Rotavirus Vaccination in Sicily.Pathogens (Basel, Switzerland) · 2026Article
- Unveiling the global urban virome through wastewater metagenomics.Nature communications · 2025Article
- Molecular Evolutionary Analyses of the RNA-Dependent RNA Polymerase (Microorganisms · 2025Article
- The outbreak of acute gastroenteritis caused by sapovirus at a school in Shenzhen, China, 2023.Frontiers in public health · 2025Article
- Viral metagenomics reveals diverse viruses in the fecal samples of children with acute respiratory infection.Frontiers in microbiology · 2025Article
- Detection and Characterization of Bacterial and Viral Acute Gastroenteritis among Outpatient Children under 5 Years Old in Guangzhou, China.The American journal of tropical medicine and hygiene · 2024Article
- Prevalence of astrovirus and sapovirus among adult oncology patients with acute gastroenteritis using a multiplexed gastrointestinal pathogen PCR panel.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2024Article
- Enhancing enteric pathogen detection: implementation and impact of multiplex PCR for improved diagnosis and surveillance.BMC infectious diseases · 2024Article
- Detection and complete genome sequence analysis of human adenovirus in children with acute diarrhea in Yunnan, China, 2015-2021.Archives of virology · 2024Article
- The analysis of the genotype of Sapovirus outbreaks in Zhejiang Province.Virology journal · 2023Article
- Characterisation of human astrovirus in a diarrhoea outbreak using nanopore and Sanger sequencing protocols.Virology journal · 2023Article
- Genotypes Diversity of Acute Gastroenteritis Outbreaks Caused by Human Sapovirus - Beijing Municipality, China, 2015-2021.China CDC weekly · 2023Article
- Acute gastroenteritis outbreaks caused by human astrovirus, 1978-2021: A systematic review.Biosafety and health · 2023Review
- Diversity of classic and novel human astrovirus in outpatient children with acute gastroenteritis in Shanghai, China.Frontiers in microbiology · 2023Article
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5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundHuman astrovirus (HAstV) and sapovirus (SaV) are common pathogens that can cause acute gastroenteritis (AGE). However, very few studies have reported the molecular epidemiology and clinical information on HAstV and SaV in China. This study aims to determine the molecular epidemiology and clinical features of HAstV and SaV in patients with AGE in Guangzhou, China.
methodsFor this study, 656 patients with AGE were enrolled. Their stool samples were screened for 15 enteropathogens using Luminex xTAG
resultsOf the 656 stool samples, 63.72% (418/656) were found to be positive, with 550 enteropathogens (296 bacteria and 254 viruses). HAstV and SaV were detected in 20 (3.0%) and 12 (1.8%) samples, respectively. Four genotypes (genotypes 1, 2, 3, and 8) of HAstV and three genotypes (GI.1, GI.2 and GIV) of SaV were identified. Coinfection was observed in ten HAstV-positive and two SaV-positive samples. HAstV was more likely to occur in winter, while SaV in early spring. The median age of the patients with single HAstV infection was higher than that of the patients with other viruses (rotavirus, norovirus, and enteric adenovirus; P = 0.0476) and unknown etiology (P = 0.006). Coinfection with HAstV or SaV were not associated with disease severity (P > 0.05).
conclusionHAstV and SaV are the common causes of AGE in Guangzhou, China.
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