Evidence map›Paper›PMID 34861767›Full record

Trial reportAIDS research and human retroviruses2022

Immunologic Change over 72 Weeks Following Raltegravir- Versus Efavirenz-Based Therapy in HIV/HCV-Coinfected Individuals in Vietnam.

Cecilia M Shikuma, Thuy Le, Thao Vu Phuong, Glen M Chew, Van Vinh Chau Nguyen, Trieu Ly Vo, Chathura Siriwardhana, Dominic Chow, Hayk Ghukasyan, Nath Limpruttidham and 4 more

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in AIDS research and human retroviruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 78% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 3 countries.

Cecilia M ShikumaHawaii Center for AIDS, Department of Medicine, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, USA.ORCID 0000-0003-0114-1262
Thuy LeHawaii Center for AIDS, Department of Medicine, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, USA.
Thao Vu PhuongDepartment of Medicine, University of Saskatchewan, Saskatoon, Canada.
Glen M ChewHawaii Center for AIDS, Department of Medicine, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, USA.
Van Vinh Chau NguyenHospital for Tropical Diseases, Ho Chi Minh City, Vietnam.
Trieu Ly VoHospital for Tropical Diseases, Ho Chi Minh City, Vietnam.
Chathura SiriwardhanaHawaii Center for AIDS, Department of Medicine, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, USA.
Dominic ChowHawaii Center for AIDS, Department of Medicine, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, USA.
Hayk GhukasyanHawaii Center for AIDS, Department of Medicine, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, USA.
Nath LimpruttidhamHawaii Center for AIDS, Department of Medicine, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, USA.
Thomas PremeauxHawaii Center for AIDS, Department of Medicine, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, USA.
Louie Mar GangcuangcoHawaii Center for AIDS, Department of Medicine, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, USA.ORCID 0000-0002-6714-9294
Robert PaulDepartment of Psychological Sciences, Missouri Institute of Mental Health, University of Missouri-St. Louis, St. Louis, Missouri, USA.
Lishomwa C NdhlovuHawaii Center for AIDS, Department of Medicine, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii, USA.ORCID 0000-0001-5427-4187
University of Hawaiʻi at Mānoa · USHospital for Tropical Diseases · VNMissouri Institute of Mental Health · USUniversity of Medicine and Pharmacy at Ho Chi Minh City · VNUniversity of Saskatchewan · CA

Funding

Social and Behavioral Sciences CoreP30AI064518 · NIAID · DUKE UNIVERSITY · PI Nwora Lance Okeke · 2005 to 2026
$50.5M
Tracking and Evaluation CoreU54GM138062 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI SHIKUMA, CECILIA M. · 2021 to 2025
$15.5M
Making an early diagnosis of talaromycosis - an approach to reduce morbidity and mortality in advanced HIV disease in Southeast AsiaR01AI143409 · NIAID · DUKE UNIVERSITY · PI LE, THUY · 2019 to 2024
$2.8M
Tropical Medicine Research Center for Talaromycosis in VietnamU01AI169358 · NIAID · DUKE UNIVERSITY · PI Thuy Le · 2022 to 2026
$2.5M
NIAID NIH HHS P30 AI064518NIAID NIH HHS R01 AI143409NIAID NIH HHS U01 AI169358
6 · The paper itself

Abstract

The impact of HIV antiretroviral therapy (ART) on immune dysregulation associated with hepatitis C virus (HCV)/HIV coinfection is incompletely understood. We serially assessed monocyte activation (neopterin, sCD14, and sCD163) and T cell activation (HLA-DR, CD38) and immune exhaustion [program cell death protein 1 (PD1), TIGIT] in HIV/HCV-coinfected individuals who participated in a randomized trial performed in Vietnam designed to assess the hepatotoxicity of raltegravir (RAL)- versus efavirenz (EFV)-based therapy when used as first-time ART in combination with tenofovir disoproxil fumarate and emtricitabine. Baseline pre-ART values were compared with those from ART-naive HIV-monoinfected and HIV-seronegative individuals. Before ART, HIV/HCV-coinfected individuals had higher levels of neopterin, sCD14, and sCD163, and increased frequencies of CD38

Indexed as

CoinfectionHepatitis CHIV InfectionsAlkynesBenzoxazinesCyclopropanesHepacivirusHLA-DR AntigensHumansLipopolysaccharide ReceptorsNeopterinRaltegravir PotassiumVietnamAlkynesBenzoxazinesCyclopropanesefavirenzHLA-DR AntigensLipopolysaccharide ReceptorsNeopterinRaltegravir Potassiumantiretroviral therapiesHIVimmune activation

Identifiers

PMID34861767
PMCPMC10027344
OpenAlexW3215324454

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.