Evidence map›Paper›PMID 34861744›Full record

ArticleAdvanced healthcare materials2022

The Coiled-Coil Forming Peptide (KVSALKE)

Jie Li, Jan Tuma, Hesong Han, Hansol Kim, Ross C Wilson, Hye Young Lee, Niren Murthy

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Cell-Penetrating Peptide Delivery for CRISPR Applications.Methods in molecular biology (Clifton, N.J.) · 2027
    Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jie LiDepartment of Bioengineering, University of California, and the Innovative Genomics Institute, 2151 Berkeley Way, Berkeley, CA, 94720, USA.ORCID 0000-0003-0189-2787
Jan TumaThe Department of Cellular and Integrative Physiology, the University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA.ORCID 0000-0002-7197-8482
Hesong HanDepartment of Bioengineering, University of California, and the Innovative Genomics Institute, 2151 Berkeley Way, Berkeley, CA, 94720, USA.
Hansol KimDepartment of Bioengineering, University of California, and the Innovative Genomics Institute, 2151 Berkeley Way, Berkeley, CA, 94720, USA.
Ross C WilsonThe Innovative Genomics Institute, 2151 Berkeley Way, Berkeley, CA, 94720, USA.
Hye Young LeeThe Department of Cellular and Integrative Physiology, the University of Texas Health Science Center at San Antonio, San Antonio, TX, 78229, USA.ORCID 0000-0002-3150-6886
Niren MurthyDepartment of Bioengineering, University of California, and the Innovative Genomics Institute, 2151 Berkeley Way, Berkeley, CA, 94720, USA.ORCID 0000-0002-7815-7337
Innovative Genomics Institute · USThe University of Texas Health Science Center at San Antonio · US

Funding

HOPE - HIV Obstruction by Programmed EpigeneticsUM1AI164559 · NIAID · J. DAVID GLADSTONE INSTITUTES · PI Lishomwa C Ndhlovu, Melanie Maria Ott · 2021 to 2026
$32.2M
Dissemination and Coordinating Center for the SCGE ConsortiumU24HG010423 · NHGRI · MEDICAL COLLEGE OF WISCONSIN · PI DWINELL, MELINDA R · 2019 to 2023
$15.0M
Gene editing in the brain with CRISPR-PEGR01MH125979 · NIMH · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI LEE, HYE YOUNG, MURTHY, NIREN · 2021 to 2025
$3.3M
Development of a Nanoparticle-Based Gene Editing Technology for Neurological ApplicationsUG3NS115599 · NINDS · OHIO STATE UNIVERSITY · PI BANKIEWICZ, KRYSTOF S, MURTHY, NIREN · 2019 to 2021
$2.3M
Single-Cell Transcriptomics of Non-Activated Latently Infected T cells Isolated from HIV+ Drug UsersR61DA048444 · NIDA · J. DAVID GLADSTONE INSTITUTES · PI OTT, MELANIE MARIA · 2019 to 2021
$2.0M
LAMIN A PROGERIA MUTATIONS AND NUCLEAR FUNCTIONR01AG023776 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GOLDMAN, ROBERT D · 2005 to 2010
$1.5M
Treatment of Duchenne Muscular Dystrophy with Cas9 Protein Complexed to Gold NanoparticlesR01EB023776 · NIBIB · UNIVERSITY OF CALIFORNIA BERKELEY · PI CONBOY, IRINA M, MURTHY, NIREN · 2017 to 2020
$1.4M
Investigating CD33 function on microglia during Alzheimer’s disease using CRISPR nanoparticlesR21AG072423 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI HOPP, SARAH CHRISTINE · 2021 to 2021
$426k
NHGRI NIH HHS U24 HG010423NHGRI NIH HHS U24HG010423NIAID NIH HHS UM1 AI164559NIA NIH HHS R21AG072423NIBIB NIH HHS R01 EB023776NIDA NIH HHS R61 DA048444NIDA NIH HHS R61DA048444NIMH NIH HHS R01 MH125979NINDS NIH HHS UG3 NS115599
6 · The paper itself

Abstract

Protein-based therapeutics have the potential to treat a variety of diseases, however, safe and effective methods for delivering them into cells need to be developed before their clinical potential can be realized. Peptide fusions have great potential for improving intracellular delivery of proteins. However, very few peptides have been identified that can increase the intracellular delivery of proteins, and new peptides that can enhance intracellular protein delivery are greatly needed. In this report, the authors demonstrate that the coiled-coil forming peptide (KVSALKE)

Indexed as

Cell-Penetrating PeptidesAnimalsBiological TransportMiceProteinsCell-Penetrating PeptidesProteinsCas9cell penetrating peptidesgene editingneurosciencenonviral deliveryprotein fusions

Identifiers

PMID34861744
PMCPMC9766156
OpenAlexW3217571889

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.