ArticleBrain stimulation
Stoney vs. Histed: Quantifying the spatial effects of intracortical microstimulation.
Article in Brain stimulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- Biomimetic stimulation patterns drive natural artificial touch percepts using intracortical microstimulation in humans.Journal of neural engineering · 2025Trial
- Computational investigation of circuit mechanisms underlying short-latency responses to cortical stimulation.bioRxiv : the preprint server for biology · 2026Article
- Neural population dynamics of direct electrical stimulation of neocortex.Cell reports · 2026Article
- The optimization of neuroprosthetic interfaces relying on biophysical and surrogate digital twins.npj biomedical innovations · 2026Review
- Neural mechanisms underlying intracortical microstimulation for sensory restoration.Nature biomedical engineering · 2026Review
- Linking spatially distributed neuronal activation overlap to the limits of perceptual discrimination in rodent primary somatosensory cortex.Frontiers in computational neuroscience · 2026Article
- Intracortical Microstimulation in Brain-Computer Interfaces: Evoking Perception and Plasticity.Cyborg and bionic systems (Washington, D.C.) · 2026Review
- Neural population dynamics of direct electrical stimulation of neocortex.bioRxiv : the preprint server for biology · 2025Article
- Disentangling indirect versus direct effects of somatosensory cortex microstimulation on neurons in primary motor and ventral premotor cortex.Journal of neural engineering · 2025Article
- Characterizing Evoked Movement Patterns and Connectivity in Sensorimotor Cortex After Sensory Loss in Squirrel Monkeys.The Journal of comparative neurology · 2025Article
- Simulation of evoked responses to transcranial magnetic stimulation using a multiscale cortical circuit model.bioRxiv : the preprint server for biology · 2025Article
- Article
- Evoking stable and precise tactile sensations via multi-electrode intracortical microstimulation of the somatosensory cortex.Nature biomedical engineering · 2025Article
- Tactile edges and motion via patterned microstimulation of the human somatosensory cortex.Science (New York, N.Y.) · 2025Article
- Towards Precise Synthetic Neural Codes: High-dimensional Stimulation with Flexible Electrodes.Npj flexible electronics · 2025Article
- Investigating the spatial limits of somatotopic and depth-dependent sensory discrimination stimuli in rats via intracortical microstimulation.Frontiers in neuroscience · 2025Article
- A Roadmap for Implanting Electrode Arrays to Evoke Tactile Sensations Through Intracortical Stimulation.Human brain mapping · 2024Article
- Basal forebrain activation improves working memory in senescent monkeys.bioRxiv : the preprint server for biology · 2024Article
- Strength of activation and temporal dynamics of bioluminescent-optogenetics in response to systemic injections of the luciferin.NeuroImage · 2024Article
- Intracortical microstimulation of human somatosensory cortex is sufficient to induce perceptual biases.medRxiv : the preprint server for health sciences · 2024Article
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5 authors.
Funding
Abstract
backgroundIntracortical microstimulation (ICMS) is used to map neural circuits and restore lost sensory modalities such as vision, hearing, and somatosensation. The spatial effects of ICMS remain controversial: Stoney and colleagues proposed that the volume of somatic activation increased with stimulation intensity, while Histed et al., suggested activation density, but not somatic activation volume, increases with stimulation intensity.
objectiveWe used computational modeling to quantify the spatial effects of ICMS intensity and unify the apparently paradoxical findings of Histed and Stoney.
methodsWe implemented a biophysically-based computational model of a cortical column comprising neurons with realistic morphology and representative synapses. We quantified the spatial effects of single pulses and short trains of ICMS, including the volume of activated neurons and the density of activated neurons as a function of stimulation intensity.
resultsAt all amplitudes, the dominant mode of somatic activation was by antidromic propagation to the soma following axonal activation, rather than via transsynaptic activation. There were no occurrences of direct activation of somata or dendrites. The volume over which antidromic action potentials were initiated grew with stimulation amplitude, while the volume of somatic activation increased marginally. However, the density of somatic activation within the activated volume increased with stimulation amplitude.
conclusionsThe results resolve the apparent paradox between Stoney and Histed's results by demonstrating that the volume over which action potentials are initiated grows with ICMS amplitude, consistent with Stoney. However, the volume occupied by the activated somata remains approximately constant, while the density of activated neurons within that volume increase, consistent with Histed.
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