Evidence map›Paper›PMID 34861316›Full record

ArticleUrology2022

Promotional Payments to Medical Oncologists and Urologists and Prescriptions for Abiraterone and Enzalutamide.

Lillian Y Lai, Mary K Oerline, Samuel R Kaufman, Lindsey A Herrel, Ted A Skolarus, Stacie B Dusetzina, Chad Ellimoottil, Vahakn B Shahinian, Brent K Hollenbeck, Megan E V Caram

Abstract read
In one paragraph

Article in Urology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Lillian Y LaiDepartments of Urology, University of Michigan, Ann Arbor, MI. Electronic address: lillianlai67@gmail.com.
Mary K OerlineDepartments of Urology, University of Michigan, Ann Arbor, MI.
Samuel R KaufmanDepartments of Urology, University of Michigan, Ann Arbor, MI.
Lindsey A HerrelDepartments of Urology, University of Michigan, Ann Arbor, MI.
Ted A SkolarusDepartments of Urology, University of Michigan, Ann Arbor, MI; Veterans Affairs Health Services Research & Development, VA Ann Arbor Healthcare System, Ann Arbor, MI.
Stacie B DusetzinaDepartment of Health Policy, Vanderbilt University School of Medicine, Nashville, TN; Vanderbilt-Ingram Cancer Center, Nashville, TN.
Chad EllimoottilDepartments of Urology, University of Michigan, Ann Arbor, MI.
Vahakn B ShahinianDepartments of Urology, University of Michigan, Ann Arbor, MI; Department of Internal Medicine, University of Michigan, Ann Arbor, MI.
Brent K HollenbeckDepartments of Urology, University of Michigan, Ann Arbor, MI.
Megan E V CaramVeterans Affairs Health Services Research & Development, VA Ann Arbor Healthcare System, Ann Arbor, MI; Department of Internal Medicine, University of Michigan, Ann Arbor, MI.

Funding

De-implementation of low value castration for men with prostate cancerR37CA222885 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SAINI, SAMEER DEV, SKOLARUS, TED ALBERT · 2018 to 2023
$3.6M
Advanced Training in Urologic OncologyT32CA180984 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Ganesh S Palapattu, VAHAKN B SHAHINIAN · 2014 to 2026
$3.4M
Impact of urologist practice organization and health policy on prostate cancer treatment, overtreatment and spendingR01HS025707 · AHRQ · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HOLLENBECK, BRENT K., SHAHINIAN, VAHAKN B · 2017 to 2021
$1.7M
Refining castration use for recurrent prostate cancerR01CA242559 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SKOLARUS, TED ALBERT, TSODIKOV, ALEXANDER · 2020 to 2023
$1.4M
Understanding the effects of the Oncology Care Model on cancer care for dual eligible patientsK08CA237638 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HERREL, LINDSEY ALLISON · 2019 to 2023
$1.1M
AHRQ HHS R01 HS025707NCI NIH HHS K08 CA237638NCI NIH HHS R01 CA242559NCI NIH HHS R37 CA222885NCI NIH HHS T32 CA180984
6 · The paper itself

Abstract

objectiveTo understand the influence of drug manufacturers on the prescribing patterns of medical oncologists and urologists, we examined the relationship between promotional payments from the manufacturers of abiraterone and enzalutamide and prescriptions for either drug by medical oncologists and urologists.

methodsPromotional payments for abiraterone or enzalutamide made to medical oncologists and urologists between January 2014 and December 2017 reported through the Open Payments Program were categorized as $0, $1$999, and $1000 or more. Prescriptions filled between January 2013 and December 2017 were identified in the Medicare Part D File. Associations between promotional payments and prescribing were assessed using generalized linear models.

resultsFrom 2013 through 2017, the number of medical oncologists and urologists prescribing abiraterone or enzalutamide increased by 38% - 298%, respectively. The odds of prescribing among medical oncologists receiving $1--$999 and those receiving $1,000 or more were 1.69 (95%CI:1.59--1.79) and 2.61 (95% CI: 2.14--3.18) times that of medical oncologists receiving no payments. Among urologists receiving $1--$999 and those receiving $1,000 or more, the odds of prescribing were 4.04 (95%CI: 3.59--4.54) and 13.57 (95%CI: 9.69--19.0) times that of urologists receiving no payments.

conclusionIncreasing promotional payments were associated with prescribing among medical oncologists and urologists, with a stronger relationship evident for urologists. Prescribing patterns for abiraterone and enzalutamide, particularly among urologists, may be influenced by payments from drug manufacturers.

Indexed as

Medicare Part DOncologistsAgedAndrostenesBenzamidesDrug IndustryDrug PrescriptionsHumansNitrilesPhenylthiohydantoinUnited StatesUrologistsabirateroneAndrostenesBenzamidesenzalutamideNitrilesPhenylthiohydantoin

Identifiers

PMID34861316
PMCPMC8940668

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.