Evidence map›Paper›PMID 34861294›Full record

ReviewNeuroscience research2022

Letting the little light of mind shine: Advances and future directions in neurochemical detection.

Nikki Tjahjono, Yihan Jin, Alice Hsu, Michael Roukes, Lin Tian

Abstract readReview
In one paragraph

Review in Neuroscience research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Review
  8. Untangling Peripheral Sympathetic Neurocircuits.Frontiers in cardiovascular medicine · 2022
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nikki TjahjonoBiomedical Engineering Graduate Group, University of California, Davis, Davis, CA, 95616, USA.
Yihan JinNeuroscience Graduate Group, University of California, Davis, Davis, CA, 95618, USA.
Alice HsuDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.
Michael RoukesDepartment of Physics, California Institute of Technology, Pasadena, CA, 91125, USA.
Lin TianDepartment of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, Davis, CA, 95616, USA. Electronic address: lintian@ucdavis.edu.

Funding

Next generation all-optical toolkits for functional analysis of neuropeptide dynamics in neural circuitsU01NS113295 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BANGHART, MATTHEW R., SABATINI, BERNARDO L · 2019 to 2022
$3.7M
Multiplex interrogation of neuromodulatory signaling in behaving animals with enhanced depth and resolutionU01NS120820 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI TIAN, LIN, VONZASTROW, MARK E · 2021 to 2024
$3.5M
Predoctoral Training in Pharmacological SciencesT32GM099608 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HELL, JOHANNES W · 2012 to 2021
$2.2M
Differentiation and Integration of Trisomy 21 iPSCs in an Animal ModelR01HD091325 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI TIAN, LIN · 2017 to 2021
$1.6M
Neuronal Integration of Newborn Granule Cells in Aged BrainsR01AG054649 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI MURRAY, KARL DANIEL · 2017 to 2021
$1.6M
Development of multi-color, bright chemigenetic indicators to image synaptic transmissionR21EY031858 · NEI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI TIAN, LIN · 2020 to 2020
$471k
NEI NIH HHS R21 EY031858NIA NIH HHS R01 AG054649NICHD NIH HHS R01 HD091325NIGMS NIH HHS T32 GM099608NINDS NIH HHS U01 NS113295NINDS NIH HHS U01 NS120820
6 · The paper itself

Abstract

Synaptic transmission via neurochemical release is the fundamental process that integrates and relays encoded information in the brain to regulate physiological function, cognition, and emotion. To unravel the biochemical, biophysical, and computational mechanisms of signal processing, one needs to precisely measure the neurochemical release dynamics with molecular and cell-type specificity and high resolution. Here we reviewed the development of analytical, electrochemical, and fluorescence imaging approaches to detect neurotransmitter and neuromodulator release. We discussed the advantages and practicality in implementation of each technology for ease-of-use, flexibility for multimodal studies, and challenges for future optimization. We hope this review will provide a versatile guide for tool engineering and applications for recording neurochemical release.

Indexed as

BrainNeurotransmitter AgentsCognitionOptical ImagingSynaptic TransmissionNeurotransmitter Agentsbiosensorsgenetically encoded indicatorsmicrodialysisneurochemistryvoltammetry

Identifiers

PMID34861294
PMCPMC9508992

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.