Evidence map›Paper›PMID 34861183›Full record

ArticleCurrent biology : CB2022

Aurora B phosphorylates Bub1 to promote spindle assembly checkpoint signaling.

Babhrubahan Roy, Simon J Y Han, Adrienne N Fontan, Soubhagyalaxmi Jema, Ajit P Joglekar

Abstract read
In one paragraph

Article in Current biology : CB, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Countervailing effects of cyclin isoforms A and B during mitosis.bioRxiv : the preprint server for biology · 2026
    Article
  6. Review
  7. Review
  8. Expression and clinical significance of BUB1 in esophageal cancer.American journal of translational research · 2025
    Article
  9. Article
  10. DeSUMOylating isopeptidase 1 participates in the faithful chromosome segregation and vincristine sensitivity.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Principles and dynamics of spindle assembly checkpoint signalling.Nature reviews. Molecular cell biology · 2023
    Review
  18. Aurora B Inhibitors as Cancer Therapeutics.Molecules (Basel, Switzerland) · 2023
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Babhrubahan RoyCell & Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Simon J Y HanCell & Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Adrienne N FontanCell & Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Soubhagyalaxmi JemaCell & Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Ajit P JoglekarCell & Developmental Biology, University of Michigan Medical School, Ann Arbor, MI 48109, USA. Electronic address: ajitj@umich.edu.

Funding

The systems biology of mitotic checkpoint signaling and its relevance to cancer cell biologyR35GM126983 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Ajit Joglekar · 2018 to 2026
$5.1M
NIGMS NIH HHS R35 GM126983
6 · The paper itself

Abstract

Accurate chromosome segregation during cell division requires amphitelic chromosome attachment to the spindle apparatus. It is ensured by the combined activity of the spindle assembly checkpoint (SAC),

Indexed as

KinetochoresM Phase Cell Cycle CheckpointsAurora Kinase BCell Cycle ProteinsHeLa CellsHumansPhosphorylationProtein Serine-Threonine KinasesSpindle ApparatusAurora Kinase BBUB1 protein, humanCell Cycle ProteinsProtein Serine-Threonine Kinasescell divisionkinetochoremitosissignalingspindle assembly checkpoint

Identifiers

PMID34861183
PMCPMC8752509

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.