Evidence map›Paper›PMID 34861158›Full record

ArticleCancer cell2022

Elimination of fluorescent protein immunogenicity permits modeling of metastasis in immune-competent settings.

Candice A Grzelak, Erica T Goddard, Emma E Lederer, Kamya Rajaram, Jinxiang Dai, Ryann E Shor, Andrea R Lim, Jeanna Kim, Slobodan Beronja, Alister P W Funnell and 1 more

Abstract readLetter
In one paragraph

Article in Cancer cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed.

  1. Article
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  10. Microglia replacement by peripheral delivery of CSF1R inhibitor-resistant hematopoietic cells.Molecular therapy : the journal of the American Society of Gene Therapy · 2026
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
  19. TIM3Cancer cell · 2025
    Article
  20. Review

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Candice A GrzelakPublic Health Sciences Division and Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. Electronic address: cgrzelak@fredhutch.org.
Erica T GoddardPublic Health Sciences Division and Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Emma E LedererPublic Health Sciences Division and Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Kamya RajaramHuman Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Jinxiang DaiPublic Health Sciences Division and Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Ryann E ShorPublic Health Sciences Division and Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Andrea R LimPublic Health Sciences Division and Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Graduate Program in Molecular and Cellular Biology, University of Washington, Seattle, WA, USA.
Jeanna KimPublic Health Sciences Division and Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Slobodan BeronjaHuman Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Alister P W FunnellAltius Institute for Biomedical Sciences, Seattle, WA, USA.
Cyrus M GhajarPublic Health Sciences Division and Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA. Electronic address: cghajar@fredhutch.org.

Funding

Differentiation balances oncogene-driven proliferation to maintain epidermal homeostasisR01AR070780 · NIAMS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Slobodan Beronja · 2017 to 2026
$4.2M
Defining and characterizing microenvironmental drivers of disseminated tumor cell dormancy in brainR01CA252874 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI GHAJAR, CYRUS M · 2020 to 2024
$2.4M
NCI NIH HHS R01 CA252874NIAMS NIH HHS R01 AR070780
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsGreen Fluorescent ProteinsHumansImmunityNeoplasm MetastasisNeoplasmsT-LymphocytesGreen Fluorescent Proteins

Identifiers

PMID34861158
PMCPMC9668376

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.