Evidence map›Paper›PMID 34861075›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2022

Central role of intestinal epithelial glucocorticoid receptor in alcohol- and corticosterone-induced gut permeability and systemic response.

Pradeep K Shukla, Avtar S Meena, Joseph F Pierre, RadhaKrishna Rao

Open access · hybridAbstract read
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Gut Microbiota-Driven Pathways Linking Chronic Stress to Tumor Progression.International journal of biological sciences · 2026
    Review
  6. Article
  7. The danger theory of immunity revisited.Nature reviews. Immunology · 2024
    Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Central role of intestinal epithelial glucocorticoid receptor in alcohol- and corticosterone-induced gut permeability and systemic response.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Pradeep K ShuklaDepartment of Physiology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Avtar S MeenaDepartment of Physiology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
Joseph F PierreDepartment of Pediatrics, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
RadhaKrishna RaoDepartment of Physiology, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee, USA.
University of Tennessee Health Science Center · USMemphis VA Medical Center · US

Funding

INTESTINAL MUCOSAL PROTECTION BY EPIDERMAL GROWTH FACTORR01DK055532 · NIDDK · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI RAO, RADHAKRISHNA · 1998 to 2020
$4.7M
MECHANISM OF ENDOTOXIN ABSORPTION IN ALCOHOLISMR01AA012307 · NIAAA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI RAO, RADHAKRISHNA · 2000 to 2014
$3.9M
Defining the Role of Intestinal Calcium Channels in Alcoholic Liver Damage.R01AA029270 · NIAAA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI RADHAKRISHNA RAO · 2022 to 2026
$2.5M
Intestinal Mucosal Protection by Epidermal Growth FactorR56DK055532 · NIDDK · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI RAO, RADHAKRISHNA · 2009 to 2009
$345k
Impact of Stress on Alcoholic Gut InjuryI01BX003014 · VA · MEMPHIS VA MEDICAL CENTER · PI RADHAKRISHNA RAO · 2017 to 2026
–
BLRD VA I01 BX003014NIAAA NIH HHS R01 AA012307NIAAA NIH HHS R01 AA029270NIDDK NIH HHS R01 DK055532NIDDK NIH HHS R56 DK055532
6 · The paper itself

Abstract

Corticosterone, the stress hormone, exacerbates alcohol-associated tissue injury, but the mechanism involved is unknown. We examined the role of the glucocorticoid receptor (GR) in corticosterone-mediated potentiation of alcohol-induced gut barrier dysfunction and systemic response. Hepatocyte-specific GR-deficient (GR

Indexed as

AnimalsCorticosteroneEscherichia coliEthanolGastrointestinal MicrobiomeIntestinal MucosaLactobacillusMiceMice, TransgenicPermeabilityReceptors, GlucocorticoidTight JunctionsCorticosteroneEthanolReceptors, Glucocorticoidendotoxemiahepatitishypothalamusinflammationtight junction

Identifiers

PMID34861075
PMCPMC8647846
OpenAlexW3216221527

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.