Evidence map›Paper›PMID 34860508›Full record

ArticleChemical research in toxicology2021

Site-Specific Synthesis of Oligonucleotides Containing 6-Oxo-M

Plamen P Christov, Robyn Richie-Jannetta, Philip J Kingsley, Anoop Vemulapalli, Kwangho Kim, Gary A Sulikowski, Carmelo J Rizzo, Amit Ketkar, Robert L Eoff, Carol A Rouzer and 1 more

Abstract read
In one paragraph

Article in Chemical research in toxicology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Plamen P ChristovDepartment of Chemistry, Vanderbilt University, Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.
Robyn Richie-JannettaA. B. Hancock, Jr., Memorial Laboratory for Cancer Research, Departments of Biochemistry, and Pharmacology, Vanderbilt Institute of Chemical Biology, and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.
Philip J KingsleyA. B. Hancock, Jr., Memorial Laboratory for Cancer Research, Departments of Biochemistry, and Pharmacology, Vanderbilt Institute of Chemical Biology, and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.
Anoop VemulapalliA. B. Hancock, Jr., Memorial Laboratory for Cancer Research, Departments of Biochemistry, and Pharmacology, Vanderbilt Institute of Chemical Biology, and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.
Kwangho KimDepartment of Chemistry, Vanderbilt University, Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.
Gary A SulikowskiDepartment of Chemistry, Vanderbilt University, Vanderbilt Institute of Chemical Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.ORCID 0000-0002-1067-0767
Carmelo J RizzoDepartments of Chemistry and Biochemistry, Vanderbilt-Ingram Cancer Center, Vanderbilt University, Nashville, Tennessee 37235, United States.
Amit KetkarDepartment of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, United States.
Robert L EoffDepartment of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, United States.ORCID 0000-0003-4776-8925
Carol A RouzerA. B. Hancock, Jr., Memorial Laboratory for Cancer Research, Departments of Biochemistry, and Pharmacology, Vanderbilt Institute of Chemical Biology, and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.ORCID 0000-0001-6827-1534
Lawrence J MarnettA. B. Hancock, Jr., Memorial Laboratory for Cancer Research, Departments of Biochemistry, Chemistry, and Pharmacology, Vanderbilt Institute of Chemical Biology, and Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States.ORCID 0000-0002-7834-6285

Funding

Chemistry and Biology of Malondialdehyde DNA AdductsR37CA087819 · NCI · VANDERBILT UNIVERSITY · PI MARNETT, LAWRENCE J. · 2005 to 2014
$4.2M
CHEMISTRY AND BIOLOGY OF MALONDIALDEHYDE DNA ADDUCTSR01CA087819 · NCI · VANDERBILT UNIVERSITY · PI MARNETT, LAWRENCE J. · 2000 to 2020
$4.0M
NCI NIH HHS R01 CA087819NCI NIH HHS R37 CA087819
6 · The paper itself

Abstract

The lipid peroxidation product malondialdehyde and the DNA peroxidation product base-propenal react with dG to generate the exocyclic adduct, M

Indexed as

Chromatography, LiquidDeoxyguanosineDNA-Directed DNA PolymeraseDNA Polymerase iotaHumansMolecular StructureOligonucleotidesTandem Mass SpectrometryDeoxyguanosineDNA-Directed DNA PolymeraseDNA Polymerase iotaOligonucleotidesPOLI protein, human

Identifiers

PMID34860508
PMCPMC10518890

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.