Evidence map›Paper›PMID 34860465›Full record

ArticleJournal of diabetes investigation2022

Association between fat mass index, fat-free mass index and hemoglobin A1c in a Japanese population: The Tohoku Medical Megabank Community-based Cohort Study.

Masato Takase, Tomohiro Nakamura, Takumi Hirata, Naho Tsuchiya, Mana Kogure, Fumi Itabashi, Naoki Nakaya, Yohei Hamanaka, Junichi Sugawara, Kichiya Suzuki and 7 more

Open access · goldAbstract read
In one paragraph

Article in Journal of diabetes investigation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 1 country.

Masato TakaseGraduate School of Medicine, Tohoku University, Sendai, Japan.ORCID https://orcid.org/0000-0001-7009-387X
Tomohiro NakamuraGraduate School of Medicine, Tohoku University, Sendai, Japan.
Takumi HirataTohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Naho TsuchiyaGraduate School of Medicine, Tohoku University, Sendai, Japan.
Mana KogureGraduate School of Medicine, Tohoku University, Sendai, Japan.
Fumi ItabashiGraduate School of Medicine, Tohoku University, Sendai, Japan.
Naoki NakayaTohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Yohei HamanakaTohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Junichi SugawaraGraduate School of Medicine, Tohoku University, Sendai, Japan.
Kichiya SuzukiTohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Nobuo FuseTohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Akira UrunoTohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Eiichi N KodamaTohoku Medical Megabank Organization, Tohoku University, Sendai, Japan.
Shinichi KuriyamaGraduate School of Medicine, Tohoku University, Sendai, Japan.
Ichiro TsujiGraduate School of Medicine, Tohoku University, Sendai, Japan.
Shigeo KureGraduate School of Medicine, Tohoku University, Sendai, Japan.
Atsushi HozawaGraduate School of Medicine, Tohoku University, Sendai, Japan.
Tohoku University · JPSaitama Prefectural University · JP

Funding

Japanese Society for the Promotion of Science 19K10637Tohoku Medical Megabank Project from the Ministry of Education, Culture, Sports, Science, and Technology (MEXT), and the Japan Agency for Medical Research and Development JP20km0105001
6 · The paper itself

Abstract

AIMS/

introductionFat mass and fat-free mass affect glycated hemoglobin A1c (HbA1c) levels and blood glucose levels, respectively. The aim of the present study was to examine the association between the fat mass index and fat-free mass index with HbA1c. MATERIALS AND

methodsWe carried out a cross-sectional study that included 3,731 men and 9,191 women aged ≥20 years, living in Miyagi Prefecture, Japan, who were not treated for diabetes. The fat mass index and fat-free mass index were calculated as fat mass and fat-free mass divided by the height squared, respectively. The indices were classified into sex-specific quartiles and combined into 16 groups. An analysis of covariance was used to assess associations between the combined fat mass index and fat-free mass index with HbA1c adjusted for potential confounders. The linear trend test was carried out by stratifying the fat mass index and fat-free mass index, entering the number as a continuous term in the regression model.

resultsIn multivariable models, a higher fat mass index was related to higher HbA1c levels in men and women in all fat-free mass index subgroups (P < 0.001 for linear trend). When we excluded the participants who had been identified as having diabetes, the fat-free mass index was also related to higher HbA1c levels in most fat mass index subgroups (P < 0.05 for linear trend).

conclusionsFat mass index was positively related to HbA1c levels. The fat-free mass index was also related to HbA1c levels when we excluded participants who had been identified as having have diabetes.

Indexed as

Adipose TissueBlood GlucoseGlycated HemoglobinBody Mass IndexCohort StudiesCross-Sectional StudiesFemaleHumansJapanMaleBlood GlucoseGlycated HemoglobinBody compositionEpidemiologyGlycated hemoglobin A1c

Identifiers

PMID34860465
PMCPMC9077739
OpenAlexW3216231723

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.