Evidence map›Paper›PMID 34860285›Full record

ArticleArchives of virology2022

Identification of heterogenous nuclear ribonucleoproteins (hnRNPs) and serine- and arginine-rich (SR) proteins that induce human papillomavirus type 16 late gene expression and alter L1 mRNA splicing.

Chengyu Hao, Lijing Gong, Xiaoxu Cui, Johanna Jönsson, Yunji Zheng, Chengjun Wu, Naoko Kajitani, Stefan Schwartz

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Chengyu HaoDepartment of Laboratory Medicine, Lund University, BMC-B13, 221 84, Lund, Sweden.
Lijing GongChina Institute of Sport and Health Sciences, Beijing Sport University, Haidian District, Beijing, People's Republic of China.
Xiaoxu CuiDepartment of Laboratory Medicine, Lund University, BMC-B13, 221 84, Lund, Sweden.
Johanna JönssonDepartment of Laboratory Medicine, Lund University, BMC-B13, 221 84, Lund, Sweden.
Yunji ZhengDepartment of Laboratory Medicine, Lund University, BMC-B13, 221 84, Lund, Sweden.
Chengjun WuSchool of Biomedical Engineering, Dalian University of Technology, Dalian, 116024, Liaoning Province, People's Republic of China.
Naoko KajitaniDepartment of Laboratory Medicine, Lund University, BMC-B13, 221 84, Lund, Sweden.
Stefan SchwartzDepartment of Laboratory Medicine, Lund University, BMC-B13, 221 84, Lund, Sweden. Stefan.Schwartz@med.lu.se.ORCID http://orcid.org/0000-0002-1249-0575
Lund University · SEUppsala University · SEBeijing Sport University · CNDalian University of Technology · CN

Funding

Cancerfonden CAN2018/702China Scholarship Council 201606525004China Scholarship Council 201607930006China Scholarship Council 201706170061China Scholarship Council 201809120016Vetenskapsrådet VR2019-01210
6 · The paper itself

Abstract

We have determined the effect of seven serine- and arginine-rich (SR) proteins and 15 heterogenous nuclear ribonucleoproteins (hnRNPs) on human papillomavirus type 16 (HPV16) late gene expression. Of the seven SR proteins analyzed here, SRSF1, SRSF3, and SRSF9 induced HPV16 late gene expression, and five of the SR proteins affected HPV16 L1 mRNA splicing. Of the 15 hnRNP proteins analyzed here, hnRNP A2, hnRNP F, and hnRNP H efficiently induced HPV16 late gene expression, and all of the hnRNPs affected HPV16 L1 mRNA levels or mRNA splicing. Thus, the majority of SR proteins and hnRNPs have the potential to regulate HPV16 L1 mRNA splicing. Strict control of the expression of the immunogenic L1 and L2 capsid proteins may contribute to the ability of HPV16 to cause persistence.

Indexed as

Heterogeneous-Nuclear RibonucleoproteinsSerineArginineGene ExpressionGene Expression Regulation, ViralHuman papillomavirus 16HumansRibonucleoproteinsRNA, MessengerSerine-Arginine Splicing FactorsArginineHeterogeneous-Nuclear RibonucleoproteinsRibonucleoproteinsRNA, MessengerSerineSerine-Arginine Splicing FactorsSRSF3 protein, human

Identifiers

PMID34860285
PMCPMC8843915
OpenAlexW3216749441

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.