Evidence map›Paper›PMID 34860157›Full record

ArticleeLife2021

Author-sourced capture of pathway knowledge in computable form using Biofactoid.

Jeffrey V Wong, Max Franz, Metin Can Siper, Dylan Fong, Funda Durupinar, Christian Dallago, Augustin Luna, John Giorgi, Igor Rodchenkov, Özgün Babur and 5 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
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  6. Clock gene Per2 modulates epidermal tissue repair in vivo.Journal of cellular biochemistry · 2024
    Article
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  12. A roadmap for the functional annotation of protein families: a community perspective.Database : the journal of biological databases and curation · 2022
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 4 countries.

Jeffrey V WongThe Donnelly Centre, University of Toronto, Toronto, Canada.ORCID 0000-0002-8912-5699
Max FranzThe Donnelly Centre, University of Toronto, Toronto, Canada.ORCID 0000-0003-0169-0480
Metin Can SiperComputational Biology Program, Oregon Health and Science University, Portland, United States.ORCID 0000-0002-7556-093X
Dylan FongThe Donnelly Centre, University of Toronto, Toronto, Canada.
Funda DurupinarComputer Science Department, University of Massachusetts Boston, Boston, United States.ORCID 0000-0002-4915-6642
Christian DallagoDepartment of Cell Biology, Harvard Medical School, Boston, United States.ORCID 0000-0003-4650-6181
Augustin LunaDepartment of Cell Biology, Harvard Medical School, Boston, United States.ORCID 0000-0001-5709-371X
John GiorgiThe Donnelly Centre, University of Toronto, Toronto, Canada.ORCID 0000-0001-9621-5046
Igor RodchenkovThe Donnelly Centre, University of Toronto, Toronto, Canada.
Özgün BaburComputer Science Department, University of Massachusetts Boston, Boston, United States.ORCID 0000-0002-0239-5259
John A BachmanLaboratory of Systems Pharmacology, Harvard Medical School, Boston, United States.ORCID 0000-0001-6095-2466
Benjamin M GyoriLaboratory of Systems Pharmacology, Harvard Medical School, Boston, United States.ORCID 0000-0001-9439-5346
Emek DemirComputational Biology Program, Oregon Health and Science University, Portland, United States.ORCID 0000-0002-3663-7113
Gary D BaderThe Donnelly Centre, University of Toronto, Toronto, Canada.ORCID 0000-0003-0185-8861
Chris SanderDepartment of Data Sciences, Dana-Farber Cancer Institute, Boston, United States.ORCID 0000-0001-6059-6270
University of Toronto · CAHarvard University · USBroad Institute · USOregon Health & Science University · USUniversity of Massachusetts Boston · USUniversity Health Network · CA

Funding

TR&D 3 - Network Guided Machine LearningP41GM103504 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI IDEKER, TREY · 2012 to 2024
$17.3M
Reactome - CoreU41HG003751 · NHGRI · ONTARIO INSTITUTE FOR CANCER RESEARCH · PI STEIN, LINCOLN D. · 2012 to 2021
$14.5M
Pathway Commons: Research Resource for Biological PathwaysU41HG006623 · NHGRI · SLOAN-KETTERING INST CAN RESEARCH · PI SANDER, CHRIS · 2012 to 2017
$5.7M
Cytoscape: A Modeling Platform for Biomolecular NetworksR01HG009979 · NHGRI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI IDEKER, TREY · 2017 to 2021
$3.5M
NHGRI NIH HHS R01 HG009979NHGRI NIH HHS U41 HG003751NHGRI NIH HHS U41 HG006623NIGMS NIH HHS P41 GM103504
6 · The paper itself

Abstract

Making the knowledge contained in scientific papers machine-readable and formally computable would allow researchers to take full advantage of this information by enabling integration with other knowledge sources to support data analysis and interpretation. Here we describe Biofactoid, a web-based platform that allows scientists to specify networks of interactions between genes, their products, and chemical compounds, and then translates this information into a representation suitable for computational analysis, search and discovery. We also report the results of a pilot study to encourage the wide adoption of Biofactoid by the scientific community.

Indexed as

Computational BiologyDatabases, FactualGenomicsPilot Projectscomputational biologycrowdsourcecuration toolgeneticsgenomicsknowledge basenonepathway analysisscience forumsystems biology

Identifiers

PMID34860157
PMCPMC8683078
OpenAlexW3215719399

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.