Evidence map›Paper›PMID 34860151›Full record

ArticleMicrobial genomics2021

Alterations in chromosomal genes

Yu Wan, Ewurabena Mills, Rhoda C Y Leung, Ana Vieira, Xiangyun Zhi, Nicholas J Croucher, Neil Woodford, Elita Jauneikaite, Matthew J Ellington, Shiranee Sriskandan

Open access · goldAbstract read
In one paragraph

Article in Microbial genomics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 32 citations in OpenAlex.

  1. Trial
  2. UropathogenicAntibiotics (Basel, Switzerland) · 2026
    Review
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  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Poultry-associated nitrofurantoin-resistant and pre-resistantOne health (Amsterdam, Netherlands) · 2025
    Article
  10. Article
  11. Phase-Specific Antibiotic Resistance Mechanisms in anbioRxiv : the preprint server for biology · 2025
    Article
  12. Molecular Characterization ofArchives of Razi Institute · 2025
    Article
  13. Article
  14. Article
  15. Unlocking Nitrofurantoin: Understanding Molecular Mechanisms of Action and Resistance in Enterobacterales.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2025
    Review
  16. Improving nitrofurantoin resistance prediction inAntimicrobial agents and chemotherapy · 2024
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Yu WanNIHR Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Department of Infectious Disease, Imperial College London, London, United Kingdom.
Ewurabena MillsNIHR Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Department of Infectious Disease, Imperial College London, London, United Kingdom.
Rhoda C Y LeungNIHR Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Department of Infectious Disease, Imperial College London, London, United Kingdom.
Ana VieiraNIHR Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Department of Infectious Disease, Imperial College London, London, United Kingdom.
Xiangyun ZhiNIHR Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Department of Infectious Disease, Imperial College London, London, United Kingdom.
Nicholas J CroucherDepartment of Infectious Disease Epidemiology, School of Public Health, Imperial College London, London, United Kingdom.
Neil WoodfordAntimicrobial Resistance and Healthcare Associated Infections Reference Unit, National Infection Service, Public Health England, Colindale, London, United Kingdom.
Elita JauneikaiteNIHR Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Department of Infectious Disease, Imperial College London, London, United Kingdom.
Matthew J EllingtonNIHR Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Department of Infectious Disease, Imperial College London, London, United Kingdom.
Shiranee SriskandanNIHR Health Protection Research Unit in Healthcare Associated Infections and Antimicrobial Resistance, Department of Infectious Disease, Imperial College London, London, United Kingdom.
NIHR Imperial Biomedical Research Centre · GBPublic Health England · GBImperial College London · GBQueen Mary Hospital · CN

Funding

Medical Research Council MR/R015600/1Medical Research Council MR/T016434/1Wellcome TrustWellcome Trust 104169/Z/14/A
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Drug Resistance, BacterialAlgorithmsEscherichia coliEscherichia coli ProteinsGene Expression Regulation, BacterialHigh-Throughput Nucleotide SequencingHumansMultienzyme ComplexesMutagenesis, InsertionalNitrofurantoinNitroreductasesSequence DeletionTranscriptional ActivationUnited KingdomUrinary Tract InfectionsWhole Genome Sequencing6,7-dimethyl-8-ribityllumazine synthaseEscherichia coli ProteinsMultienzyme ComplexesNfsA protein, E coliNfsB protein, E coliNitrofurantoinNitroreductasesantimicrobial resistancechromosomal mutationsEscherichia coliNitrofurantoinPredicting resistanceresistance mechanisms

Identifiers

PMID34860151
PMCPMC8767348
OpenAlexW3215490393

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.