Evidence map›Paper›PMID 34859887›Full record

Observational studyJournal of the American Geriatrics Society2022

Colonoscopy utilization and outcomes in older adults: Data from the New Hampshire Colonoscopy Registry.

Audrey H Calderwood, Tor D Tosteson, Louise C Walter, Peiying Hua, Tracy Onega

Open access · greenAbstract readObservational Study
In one paragraph

Observational study in Journal of the American Geriatrics Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Quality indicators for colonoscopy.Gastrointestinal endoscopy · 2024
    Guideline
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Observational
  7. Review
  8. Review
  9. Quality Indicators for Colonoscopy.The American journal of gastroenterology · 2024
    Article
  10. Article
  11. An abdominal vibration combined with walking exercise (AVCWE) program for older patients with constipation: Development and feasibility study.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association · 2024
    Article
  12. Article
  13. Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Audrey H CalderwoodDepartment of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA.ORCID 0000-0001-7486-8310
Tor D TostesonDepartment of Health Policy and Clinical Practice, Dartmouth's Geisel School of Medicine, Hanover, NH, USA.ORCID 0000-0001-9302-4762
Louise C WalterDepartment of Medicine, San Francisco VA Health Care System, San Francisco, CA, USA.ORCID 0000-0002-9642-6238
Peiying HuaDepartment of Biomedical Data Science and Community and Family Medicine, Dartmouth's Geisel School of Medicine, Hanover, NH, USA.
Tracy OnegaDepartment of Population Health Sciences, University of Utah, Huntsman Cancer Institute, Salt Lake City, UT, USA.ORCID 0000-0002-1633-3040
Dartmouth College · USUniversity of California, San Francisco · USUniversity of Utah · US

Funding

Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Fred W Kolling IV · 1985 to 2026
$91.3M
SYNERGY: The Dartmouth Center for clinical and Translational ScienceUL1TR001086 · NCATS · DARTMOUTH COLLEGE · PI GREEN, ALAN I · 2013 to 2017
$18.3M
NH COMPREHENSIVE CANCER CONTROL PROGRAM & CANCER REGISTRYU58DP003930 · DP · NH STATE DEPT/HLTH STATISTICS/DATA MGMT · PI MONTERO, JOSE THEIR · 2012 to 2014
$7.0M
Reducing Inappropriate Use of Surveillance Colonoscopy in Older AdultsR21CA227776 · NCI · DARTMOUTH-HITCHCOCK CLINIC · PI CALDERWOOD, AUDREY HONG · 2019 to 2020
$375k
CDC HHS 5U58DP003930NCATS NIH HHS UL1 TR001086NCATS NIH HHS UL1TR001086NCCDPHP CDC HHS U58 DP003930NCI NIH HHS 5P30CA023108NCI NIH HHS P30 CA023108NCI NIH HHS R21 CA227776
6 · The paper itself

Abstract

backgroundColonoscopy is frequently performed in older adults, yet data on current use, and clinical outcomes of and follow-up recommendations after colonoscopy in older adults are lacking.

methodsThis was an observational study using the New Hampshire Colonoscopy Registry of adults age ≥65 years undergoing colonoscopy for screening, surveillance of prior polyps, or evaluation of symptoms. The main outcomes were clinical findings of polyps and colorectal cancer and recommendations for future colonoscopy by age.

resultsBetween 2009 and 2019, there were 42,611 colonoscopies, of which 17,527 (41%) were screening, 19,025 (45%) surveillance, and 6059 (14%) for the evaluation of symptoms. Mean age was 71.1 years (SD 5.0), and 49.3% were male. The finding of colorectal cancer was rare (0.71%), with the highest incidence among diagnostic examinations (2.4%). The incidence of advanced polyps increased with patient age from 65-69 to ≥85 years for screening (7.1% to 13.6%; p = 0.05) and surveillance (9.4% to 12.0%; p < 0.001). Recommendations for future colonoscopy decreased with age and varied by findings at current colonoscopy. In patients without any significant findings, 85% aged 70-74 years, 61.9% aged 75-79 years, 39.1% aged 80-84 years, and 27.4% aged ≥85 years (p < 0.001) were told to continue colonoscopy. Among patients with advanced polyps, 97.2% aged 70-74 years, 89.6% aged 75-79 years, 78.4% aged 80-84 years, and 66.7% aged ≥85 years were told to continue colonoscopy (p < 0.001).

conclusionsWithin this comprehensive statewide registry, clinical findings during colonoscopy varied by indication and increased with age. Overall rates of finding advanced polyps and colorectal cancer are low. Older adults are frequently recommended to continue colonoscopy despite advanced age and insignificant clinical findings on current examination. These data inform the potential benefits of ongoing colonoscopy, which must be weighed with the low but known potential immediate and long-term harms of colonoscopy, including cost, psychological distress, and long lag time to benefit exceeding life expectancy.

Indexed as

Colorectal NeoplasmsAgedColonoscopyFemaleHumansMaleMass ScreeningNew HampshireRegistriesagecolorectal cancer screeningpolyp surveillancerecommendations

Identifiers

PMID34859887
PMCPMC8904292
OpenAlexW3215937997

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.