Evidence map›Paper›PMID 34859780›Full record

ArticleeLife2021

Simultaneous recording of multiple cellular signaling events by frequency- and spectrally-tuned multiplexing of fluorescent probes.

Michelina Kierzek, Parker E Deal, Evan W Miller, Shatanik Mukherjee, Dagmar Wachten, Arnd Baumann, U Benjamin Kaupp, Timo Strünker, Christoph Brenker

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Design principles of ciliary signaling.Journal of cell science · 2025
    Review
  3. Article
  4. Article
  5. The sperm-specific KFrontiers in cell and developmental biology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Michelina KierzekCentre of Reproductive Medicine and Andrology, University of Münster, Münster, Germany.
Parker E DealDepartment of Chemistry, University of California, Berkeley, Berkeley, United States.
Evan W MillerDepartment of Chemistry, University of California, Berkeley, Berkeley, United States.ORCID 0000-0002-6556-7679
Shatanik MukherjeeMolecular Sensory Systems, Center of Advanced European Studies and Research, Bonn, Germany.ORCID 0000-0002-7359-9339
Dagmar WachtenInstitute of Innate Immunity, Department of Biophysical Imaging, Medical Faculty, University of Bonn, Bonn, Germany.ORCID 0000-0003-4800-6332
Arnd BaumannInstitute of Biological Information Processing (IBI-1), Research Center Jülich, Jülich, Germany.
U Benjamin KauppLife & Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany.
Timo Strünker *Centre of Reproductive Medicine and Andrology, University of Münster, Münster, Germany.ORCID 0000-0003-0812-1547
Christoph Brenker *Centre of Reproductive Medicine and Andrology, University of Münster, Münster, Germany.ORCID 0000-0002-4230-2571

Funding

New Chemical Tools for Exploring Cellular PhysiologyR35GM119855 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI MILLER, EVAN WALKER · 2016 to 2020
$1.3M
NIGMS NIH HHS R35 GM119855
6 · The paper itself

Abstract

Fluorescent probes that change their spectral properties upon binding to small biomolecules, ions, or changes in the membrane potential (V

Indexed as

AnimalsArbaciaBiosensing TechniquesFluorescent DyesMaleSpermatozoaFluorescent DyesArbacia punctulatacell biologyfluorescence multiplexingsignal transductionvoltage-sensitive dye

Identifiers

PMID34859780
PMCPMC8700268

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.