ArticleBrazilian journal of cardiovascular surgery2022
Retrospective Evaluation of Platelet-Leukocyte Indices and Cardiac Surgical Outcomes in Acyanotic Heart Disease Patients with Pulmonary Hypertension (REPLICA-PH).
Article in Brazilian journal of cardiovascular surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 15 citations in OpenAlex.
- Prognostic Value of Neutrophil-to-Lymphocyte Ratio for Adverse Outcomes in Pediatric Congenital Heart Disease Surgery.Avicenna journal of medicine · 2026Review
- Evaluation of nosocomial infections after congenital heart surgery in children: a comprehensive analysis including the systemic immune-inflammation index.Frontiers in pediatrics · 2026Article
- Article
- Prognostic value of neutrophil-lymphocyte ratio, absolute lymphocyte count, and thrombocyte-lymphocyte ratio in predicting the outcomes of tetralogy of fallot primary repair.Frontiers in cardiovascular medicine · 2025Article
- The association between systemic immune-inflammation index (SII) and early nosocomial infections after cardiopulmonary bypass surgery in children with congenital heart disease.BMC cardiovascular disorders · 2024Article
- In reply: Additional Insights into the REPLICA-PH study.Brazilian journal of cardiovascular surgery · 2024Article
- Comment on: "Evaluation of perioperative risk factors in pediatric patients with left ventricle outflow tract obstruction".Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery · 2024Article
- Value of the neutrophil-to-lymphocyte ratio in chronic obstructive pulmonary disease complicated with pulmonary hypertension.The Journal of international medical research · 2023Article
- Additional Insights into the REPLICA-PH Study.Brazilian journal of cardiovascular surgery · 2023Article
- Association of Systemic Immune Inflammation Index with Estimated Pulse Wave Velocity, Atherogenic Index of Plasma, Triglyceride-Glucose Index, and Cardiovascular Disease: A Large Cross-Sectional Study.Mediators of inflammation · 2023Article
- The outcome of surgery for congenital heart disease in India: A systematic review and metanalysis.Annals of pediatric cardiologyArticle
- Nonanalgesic benefits of thoracic epidurals in pediatric cardiac surgery: The nitty gritty.Medical journal, Armed Forces IndiaArticle
- Transoesophageal echocardiography following ventricular septal defect repair: A retrospective case series on the upcoming role of right ventricular-pulmonary arterial uncoupling.Journal of anaesthesiology, clinical pharmacologyArticle
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7 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
introductionAcyanotic congenital heart disease (ACHD) patients with pulmonary hypertension (PH) are prone to postoperative complications, and characterization of the risk profile continues to fail in identifying inflammatory predilection. Our objective is to investigate the role of platelet-leukocyte indices (neutrophil-lymphocyte ratio [NLR], platelet-lymphocyte ratio [PLR], and systemic immune-inflammation index [SII] [neutrophil × platelet/lymphocyte]) in predicting poor outcomes following cardiac surgery in ACHD cohort with preoperative PH.
methodsThis single-center, retrospective risk-predictive study included ACHD patients undergoing surgical correction at our tertiary cardiac center between January 2015 and December 2019. Standard institutional perioperative management protocol was followed, and poor postoperative outcome was defined as ≥ 1 of: low cardiac output syndrome, new-onset renal failure, prolonged mechanical ventilation (MV > 24 hours), stroke, sepsis, and/or death.
resultsOne hundred eighty patients out of 1,040 (17.3%) presented poor outcome. On univariate analysis, preoperative factors including right ventricular systolic pressure (RVSP) (PH-severity marker), congestive heart failure, albumin, NLR, PLR, SII, and aortic cross-clamping (ACC) and cardiopulmonary bypass (CPB) times predicted poor outcome. However, on multivariate analysis, RVSP, NLR, SII, and ACC and CPB times emerged as independent predictors. An NLR, SII prognostic cutoff of 3.33 and 860.6×103/mm3 was derived (sensitivity: 77.8%, 78.9%; specificity: 91.7%, 82.2%; area under the curve: 0.871, 0.833). NLR and SII values significantly correlated with postoperative MV duration, mean vasoactive-inotropic scores, and length of intensive care unit and hospital stay (P<0.001).
conclusionNovel parsimonious, reproducible plateletleukocyte indices present the potential of stratifying the risk in congenital cardiac surgical patients with pre-existing PH.
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