Evidence map›Paper›PMID 34859584›Full record

ArticleInfluenza and other respiratory viruses2022

Impact of diabetes status on immunogenicity of trivalent inactivated influenza vaccine in older adults.

Sarah Spencer, Jessie R Chung, Edward A Belongia, Maria Sundaram, Jennifer Meece, Laura A Coleman, Richard K Zimmerman, Mary Patricia Nowalk, Krissy Moehling Geffel, Ted Ross and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Influenza and other respiratory viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Observational
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 3 countries.

Sarah SpencerInfluenza Division, US Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Jessie R ChungInfluenza Division, US Centers for Disease Control and Prevention, Atlanta, Georgia, USA.ORCID 0000-0001-5205-966X
Edward A BelongiaCenter for Clinical Epidemiology & Population Health, Marshfield Clinic Research Institute, Marshfield, Wisconsin, USA.ORCID 0000-0001-7478-0415
Maria SundaramCenter for Clinical Epidemiology & Population Health, Marshfield Clinic Research Institute, Marshfield, Wisconsin, USA.ORCID 0000-0001-8056-3302
Jennifer MeeceCenter for Clinical Epidemiology & Population Health, Marshfield Clinic Research Institute, Marshfield, Wisconsin, USA.
Laura A ColemanTranslational Medicine, Novartis Institutes for Biomedical Research, Basel, Switzerland.
Richard K ZimmermanSchools of Medicine Department of Family Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Mary Patricia NowalkSchools of Medicine Department of Family Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-1702-2690
Krissy Moehling GeffelSchools of Medicine Department of Family Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-2103-4096
Ted RossCenter for Vaccines and Immunology, Department of Infectious Diseases, University of Georgia, Athens, Georgia, USA.ORCID 0000-0003-1947-7469
Chalise E CarterCenter for Vaccines and Immunology, Department of Infectious Diseases, University of Georgia, Athens, Georgia, USA.
David ShayInfluenza Division, US Centers for Disease Control and Prevention, Atlanta, Georgia, USA.ORCID 0000-0001-9619-4820
Min LevineInfluenza Division, US Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Justine LiepkalnsInfluenza Division, US Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Jin Hyang KimInfluenza Division, US Centers for Disease Control and Prevention, Atlanta, Georgia, USA.ORCID 0000-0001-6786-3482
Suryaprakash SambharaInfluenza Division, US Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Mark G ThompsonInfluenza Division, US Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Brendan FlanneryInfluenza Division, US Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Centers for Disease Control and Prevention · USMarshfield Clinic · USUniversity of Pittsburgh · USUniversity of Georgia · USNovartis (Switzerland) · CH

Funding

UNIVERSITY OF PITTSBURGH CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE: BPCAUL1RR024153 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2006 to 2011
$73.9M
University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8M
Core_plus Option_A_C_Influenza Surveillance and Vaccine Effectiveness in a LargeU01IP000467 · IP · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ZIMMERMAN, RICHARD K · 2011 to 2015
$5.9M
Core_plus Option_B_C_Influenza Vaccine Effectiveness in a Wisconsin PopulationU01IP000471 · IP · MARSHFIELD CLINIC RESEARCH FOUNDATION · PI BELONGIA, EDWARD · 2011 to 2015
$5.6M
NCATS NIH HHS UL1 TR000005NCIRD CDC HHS U01 IP000467NCIRD CDC HHS U01 IP000471NCRR NIH HHS UL1 RR024153
6 · The paper itself

Abstract

Individuals with type 2 diabetes mellitus experience high rates of influenza virus infection and complications. We compared the magnitude and duration of serologic response to trivalent influenza vaccine in adults aged 50-80 with and without type 2 diabetes mellitus. Serologic response to influenza vaccination was similar in both groups: greater fold-increases in antibody titer occurred among participants with lower pre-vaccination antibody titers. Waning of antibody titers was not influenced by diabetes status.

Indexed as

Diabetes Mellitus, Type 2Influenza, HumanInfluenza VaccinesAgedAged, 80 and overAntibodies, ViralHemagglutination Inhibition TestsHumansInfluenza A Virus, H3N2 SubtypeMiddle AgedVaccines, InactivatedAntibodies, ViralInfluenza VaccinesVaccines, Inactivatedinfluenzaserologic responsevaccine

Identifiers

PMID34859584
PMCPMC8983908
OpenAlexW3214861047

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.