Evidence map›Paper›PMID 34859468›Full record

ArticlePaediatric and perinatal epidemiology2022

Relationship between pre-pregnancy maternal body mass index and infant weight trajectories in HIV-exposed and HIV-unexposed infants.

Angela M Bengtson, Stanzi M le Roux, Tamsin K Phillips, Kirsty Brittain, Allison Zerbe, Hlengiwe P Madlala, Thokozile R Malaba, Gregory Petro, Elaine J Abrams, Landon Myer

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In one paragraph

Article in Paediatric and perinatal epidemiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Angela M BengtsonDepartment of Epidemiology, Brown University School of Public Health, Providence, Rhode Island, USA.ORCID 0000-0003-1305-8132
Stanzi M le RouxDivision of Epidemiology and Biostatistics, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa.
Tamsin K PhillipsDivision of Epidemiology and Biostatistics, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa.
Kirsty BrittainDivision of Epidemiology and Biostatistics, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa.
Allison ZerbeICAP at Columbia University, Mailman School of Public Health, Columbia University, New York, New York, USA.
Hlengiwe P MadlalaDivision of Epidemiology and Biostatistics, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa.
Thokozile R MalabaDivision of Epidemiology and Biostatistics, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa.ORCID 0000-0003-0938-5587
Gregory PetroDepartment of Obstetrics & Gynaecology, University of Cape Town and New Somerset Hospital, Cape Town, South Africa.
Elaine J AbramsICAP at Columbia University, Mailman School of Public Health, Columbia University, New York, New York, USA.
Landon MyerDivision of Epidemiology and Biostatistics, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa.
University of Cape Town · ZAICAP Global HealthBrown University · US

Funding

Fogarty Global Health Fellows Coordinating CenterR25TW009340 · FIC · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CHI, BENJAMIN H. · 2012 to 2016
$6.9M
Strategies to optimize ART services for maternal&child health: the MCH-ART studyR01HD074558 · NICHD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ABRAMS, ELAINE JANINE, MYER, BENJAMIN LANDON · 2012 to 2014
$2.9M
An Implementation Science Approach to Monitoring Engagement in HIV CareR00MH112413 · NIMH · BROWN UNIVERSITY · PI BENGTSON, ANGELA · 2019 to 2021
$747k
FIC NIH HHS R25 TW009340NICHD NIH HHS R01 HD074558NIMH NIH HHS R00 MH112413PEPFAR
6 · The paper itself

Abstract

backgroundMaternal HIV and antiretroviral therapy (ART) exposure in utero may influence infant weight, but the contribution of maternal y body mass index (BMI) to early life overweight and obesity is not clear.

objectiveTo estimate associations between maternal BMI at entry to antenatal care (ANC) and infant weight through approximately 1 year of age and to evaluate whether associations were modified by maternal HIV status, maternal HIV and viral load, breastfeeding intensity through 6 months or timing of entry into ANC.

methodsWe followed HIV-uninfected and -infected pregnant women initiating efavirenz-based ART from first antenatal visit through 12 months postpartum. Infant weight was assessed via World Health Organization BMI and weight-for-length z-scores (WLZ) at 6 weeks, 3, 6, 9 and 12 months. We used multivariable linear mixed-effects models to estimate associations between maternal BMI and infant z-scores over time.

resultsIn 861 HIV-uninfected infants (454 HIV-exposed; 407 HIV-unexposed), nearly 20% of infants were overweight or obese by 12 months of age, regardless of HIV exposure status. In multivariable analyses, increasing maternal BMI category was positively associated with higher infant BMIZ and WLZ scores between 6 weeks and 12 months of age and did not differ by HIV exposure status. However, HIV-exposed infants had slightly lower BMIZ and WLZ trajectories through 12 months of age, compared with HIV-unexposed infants across all maternal BMI categories. Differences in BMIZ and WLZ scores by HIV exposure were not explained by timing of entry into ANC or maternal viral load pre-ART initiation, but z-scores were slightly higher for HIV-exposed infants who were predominantly or exclusively versus partially breastfed.

conclusionsThese findings suggest maternal BMI influences early infant weight gain, regardless of infant HIV exposure status. Intervention to reduce maternal BMI may help to address growing concerns about obesity among HIV-uninfected children.

Indexed as

Body-Weight TrajectoryHIV InfectionsPregnancy Complications, InfectiousBody Mass IndexBreast FeedingChildFemaleHumansInfantObesityOverweightPregnancyBMIHIVHIV-exposedinfant growthinfant weightSouth Africa

Identifiers

PMID34859468
PMCPMC9163208
OpenAlexW3215441861

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.