Evidence map›Paper›PMID 34859371›Full record

ArticleClinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico2022

Long non-coding RNA PVT1 facilitates cell migration and invasion by regulating miR-148a-3p and ROCK1 in breast cancer.

H L Li, C P Wang, Y Zhang, J X Du, L H Han, H Y Yang

Abstract read
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In one paragraph

Article in Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Cancer cell-extrinsic STING shapes immune-active microenvironment and predicts clinical outcome in gastric cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

H L LiEmergency Department, Weifang People's Hospital, Weifang, 261041, China.ORCID http://orcid.org/0000-0002-5177-0932
C P WangBreast Diagnosis and Treatment Center, Affiliated Qingdao Central Hospital, Qingdao University, Qingdao, 266042, China.ORCID http://orcid.org/0000-0002-5568-728X
Y ZhangRadiology Department, Affiliated Qingdao Central Hospital, Qingdao University, Qingdao, 266042, China.ORCID http://orcid.org/0000-0002-1887-3649
J X DuDepartment of Neurology, the People's Hospital of Zhangqiu Area, Jinan, 250200, China.ORCID http://orcid.org/0000-0001-9695-4359
L H HanDepartment of Health Examination, the People's Hospital of Zhangqiu Area, Jinan, 250200, China.ORCID http://orcid.org/0000-0002-9910-3549
H Y YangDepartment of Oncology, Jinan Central Hospital, 105 Jiefang Road, Jinan, 250013, Shandong, China. zym071222@163.com.ORCID http://orcid.org/0000-0002-5754-9120
Qingdao University · CNZhangqiu City People's Hospital · CNJinan Central Hospital · CNWeifang People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeBreast cancer (BC) is one of the most common malignant tumors for women. The role and potential mechanisms of long non-coding RNA plasmacytoma variant translocation 1 (lncRNA PVT1) were explored in BC cell migration and invasion.

methodsPVT1, miR-148a-3p and Rho‑associated, coiled‑coil containing protein kinase 1 (ROCK1) mRNA expressions were detected using real-time fluorescent quantitative polymerase chain reaction (qRT-PCR). The ROCK1 protein expression was detected by Western blotting. The relationship of PVT1, miR-148a-3p and ROCK1 was analyzed by Dual Luciferase activity, RNA immunoprecipitation (RIP) and Spearman correlation analysis. Cell invasion and migration were detected by Transwell assay.

resultsUpregulation of PVT1 and ROCK1, and downregulation of miR-148a-3p were observed in BC tissues and cell lines. According to the analysis of Dual Luciferase activity, RIP and Spearman correlation analysis, miR-148a-3p directly binds to PVT1, and ROCK1 is a target of miR-148a-3p. In addition, PVT1 regulated the cells migration and invasion by regulating miR-148a-3p and ROCK1 expression.

conclusionThese data demonstrated that PVT1 was upregulated and facilitated to the cell migration and invasion of BC by the regulation of miR-148a-3p and ROCK1, indicating that PVT1 may be a potential biomarker of BC diagnosis and treatment.

Indexed as

Breast NeoplasmsMicroRNAsCell Line, TumorCell MovementCell ProliferationFemaleGene Expression Regulation, NeoplasticHumansLuciferasesrho-Associated KinasesRNA, Long NoncodingLuciferasesMicroRNAsPVT1 long-non-coding RNA, humanrho-Associated KinasesRNA, Long NoncodingROCK1 protein, humanBreast cancerCell invasionCell migrationOncogenePVT1

Identifiers

PMID34859371
OpenAlexW3216247075

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.