Evidence map›Paper›PMID 34859339›Full record

ArticleJournal of autism and developmental disorders2023

Sex Differences in Autism: Examining Intrinsic and Extrinsic Factors in Children and Adolescents Enrolled in a National ASD Cohort.

Emily F Dillon, Stephen Kanne, Rebecca J Landa, Robert Annett, Raphael Bernier, Catherine Bradley, Laura Carpenter, So Hyun Kim, Julia Parish-Morris, Robert Schultz and 2 more

Open access · greenAbstract read
In one paragraph

Article in Journal of autism and developmental disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

  1. The use of Language ENvironment Analysis in autism research: A systematic review.Autism : the international journal of research and practice · 2025
    Pooled it
  2. Sex Differences in Autistic Youth Born Extremely Preterm.Journal of autism and developmental disorders · 2026
    Article
  3. Article
  4. Relations Between Preferential Looking to Synchronous Audiovisual Speech and Expressive Language in Infants With Autistic and Non-Autistic Siblings.Mind, brain and education : the official journal of the International Mind, Brain, and Education Society · 2026
    Article
  5. Article
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  8. Comparative Analysis of Autistic Women Across the Lifespan: Childhood vs. Adulthood Diagnosis.Autism research : official journal of the International Society for Autism Research · 2025
    Article
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  16. Measurement invariance of the Autism Impact Measure (AIM) across sex in children with autism spectrum disorder.Autism research : official journal of the International Society for Autism Research · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Emily F DillonJohns Hopkins University School of Medicine, Baltimore, MD, USA.
Stephen KanneThompson Center of Neurodevelopmental Disorders, University of Missouri, Columbia, MO, USA.
Rebecca J LandaJohns Hopkins University School of Medicine, Baltimore, MD, USA.
Robert AnnettDepartment of Pediatrics, University of Mississippi Medical Center, Jackson, MS, USA.
Raphael BernierDepartment of Psychiatry, University of Washington, Seattle, WA, USA.
Catherine BradleyDevelopmental-Behavioral Pediatrics, Medical University of South Carolina, Charleston, SC, USA.
Laura CarpenterDevelopmental-Behavioral Pediatrics, Medical University of South Carolina, Charleston, SC, USA.
So Hyun KimWeill Cornell Medicine, Clinical Psychiatry, New York, NY, USA.
Julia Parish-MorrisCenter for Autism and Children's Hospital of Philadelphia, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Robert SchultzCenter for Autism and Children's Hospital of Philadelphia, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Ericka L WodkaJohns Hopkins University School of Medicine, Baltimore, MD, USA. wodka@kennedykrieger.org.ORCID http://orcid.org/0000-0002-4855-5895
SPARK consortium
Kennedy Krieger Institute · USChildren's Hospital of Philadelphia · USCornell University · USMedical University of South Carolina · USJackson Memorial Hospital · USUniversity of Washington · US

Funding

Sleep and Circadian Dysfunction, Brain and Neurobehavioral Development in AutismP50HD103538 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI S. Ali Fatemi, Bradley L Schlaggar · 2020 to 2026
$9.9M
The Intellectual and Developmental Disabilities Research Center (IDDRC) at CHOP/PennP50HD105354 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI ERIC D MARSH, ROBERT Thomas SCHULTZ · 2021 to 2026
$9.2M
J. NRSA Training CoreTL1TR002388 · NCATS · UNIVERSITY OF CHICAGO · PI ALI KESHAVARZIAN, Sonia Kupfer · 2017 to 2026
$6.7M
The Intellectual and Developmental Disabilities Research Center at CHOP/PennU54HD086984 · NICHD · CHILDREN'S HOSP OF PHILADELPHIA · PI SCHULTZ, ROBERT THOMAS · 2016 to 2020
$6.3M
FITting noninvasive testing into Lynch syndrome colorectal cancer surveillance: a multicenter, prospective trialR01CA287257 · NCI · UNIVERSITY OF CHICAGO · PI Fay Kastrinos, Sonia Kupfer · 2024 to 2026
$3.4M
NCATS NIH HHS TL1 TR002388NCI NIH HHS R01 CA287257NICHD NIH HHS P50 HD103538NICHD NIH HHS P50 HD105354NICHD NIH HHS U54 HD086984Simons Foundation 534041
6 · The paper itself

Abstract

Discernment of possible sex-based variations in presentations of autism spectrum disorder (ASD) symptoms is limited by smaller female samples with ASD and confounds with ASD ascertainment. A large national cohort of individuals with autism, SPARK, allowed parent report data to be leveraged to examine whether intrinsic child characteristics and extrinsic factors differentially impact males and females with ASD. Small but consistent sex differences in individuals with ASD emerged related to both intrinsic and extrinsic factors, with different markers for males and females. Language concerns in males may make discernment of ASD more straightforward, while early motor concerns in females may hamper diagnosis as such delays are not identified within traditional ASD diagnostic criteria.

Indexed as

Autism Spectrum DisorderAutistic DisorderAdolescentChildFemaleHumansLanguageMaleSex CharacteristicsSex FactorsASDAutism spectrum disorderDiagnosisSex/gender differences

Identifiers

PMID34859339
PMCPMC9181723
OpenAlexW3214777181

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.