Evidence map›Paper›PMID 34859288›Full record

ArticleExperimental brain research2022

Effects of low-frequency repetitive transcranial magnetic stimulation in adductor laryngeal dystonia: a safety, feasibility, and pilot study.

Cecília N Prudente, Mo Chen, Kaila L Stipancic, Katherine L Marks, Sharyl Samargia-Grivette, George S Goding, Jordan R Green, Teresa J Kimberley

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental brain research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02957942 (Repetitive Transcranial Magnetic Stimulation in Spasmodic Dysphonia), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02957942 nacompletednot on this map

Repetitive Transcranial Magnetic Stimulation in Spasmodic Dysphonia

TypeinterventionalSponsorUniversity of MinnesotaRan2017 to 2018Enrolled20ConditionsSpasmodic Dysphonia, Laryngeal DystoniaArms1Hz repetitive transcranial magnetic stimulation (rTMS)
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

  1. Laryngeal dystonia: a comprehensive review of aetiology, clinical presentation, diagnosis, and treatment approaches.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Cecília N PrudenteDivisions of Physical Therapy and Rehabilitation Science, Department of Rehabilitation Medicine, School of Medicine, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0003-1296-8062
Mo ChenNon-Invasive Neuromodulation Laboratory, MnDRIVE Initiative, University of Minnesota, Minneapolis, MN, USA.ORCID http://orcid.org/0000-0002-3188-166X
Kaila L StipancicDepartment of Communication Sciences and Disorders, School of Health and Rehabilitation Sciences, MGH Institute of Health Professions, Boston, MA, USA.ORCID http://orcid.org/0000-0001-5185-563X
Katherine L MarksDepartment of Communication Sciences and Disorders, School of Health and Rehabilitation Sciences, MGH Institute of Health Professions, Boston, MA, USA.ORCID http://orcid.org/0000-0001-5483-3794
Sharyl Samargia-GrivetteDepartment of Communication Sciences and Disorders, University of Minnesota-Duluth, Duluth, MN, USA.
George S GodingDepartment of Otolaryngology-Head and Neck Surgery, University of Minnesota, Minneapolis, MN, USA.
Jordan R GreenDepartment of Communication Sciences and Disorders, School of Health and Rehabilitation Sciences, MGH Institute of Health Professions, Boston, MA, USA.ORCID http://orcid.org/0000-0002-1464-1373
Teresa J KimberleyDivisions of Physical Therapy and Rehabilitation Science, Department of Rehabilitation Medicine, School of Medicine, University of Minnesota, Minneapolis, MN, USA. tkimberley@mgh.harvard.edu.ORCID http://orcid.org/0000-0001-6397-4054
University of Minnesota · USMGH Institute of Health Professions · USBoston University · USUniversity of Minnesota, Duluth · US

Funding

Use of ambulatory biofeedback to improve behavioral treatment of vocal hyperfunctionP50DC015446 · NIDCD · MASSACHUSETTS GENERAL HOSPITAL · PI Robert E Hillman · 2017 to 2026
$25.5M
A Multimodal Assessment of Neurophysiology in Focal DystoniaR01DC015216 · NIDCD · UNIVERSITY OF MINNESOTA · PI KIMBERLEY, TERESA JACOBSON · 2017 to 2021
$1.6M
The effects of neural modulation on phonatory function in laryngeal dystoniaK24DC018603 · NIDCD · MGH INSTITUTE OF HEALTH PROFESSIONS · PI KIMBERLEY, TERESA JACOBSON · 2021 to 2025
$978k
Pathophysiology of Spasmodic Dysphonia: a TMS studyR21DC012344 · NIDCD · UNIVERSITY OF MINNESOTA · PI KIMBERLEY, TERESA JACOBSON · 2012 to 2013
$394k
NIDCD NIH HHS K24 DC018603NIDCD NIH HHS P50 DC015446NIDCD NIH HHS P50DC015446NIDCD NIH HHS R01 DC015216NIDCD NIH HHS R1DC012344NIDCD NIH HHS R21 DC012344NIDCD NIH HHS R21DC012344
6 · The paper itself

Abstract

purposeThe effects of neuromodulation are virtually unexplored in adductor laryngeal dystonia (AdLD), a disorder characterized by involuntary contraction of intrinsic laryngeal muscles. Recent findings indicated that intracortical inhibition is reduced in people with AdLD. Low-frequency repetitive transcranial magnetic stimulation (rTMS) induces prolonged intracortical inhibition, but the effects in AdLD are unexplored. This pilot and feasibility study aimed to examine the safety, feasibility, and effects of a single session 1 Hz rTMS over the laryngeal motor cortex (LMC) in people with AdLD and healthy individuals.

methodsThe stimulation location was individualized and determined through TMS-evoked responses in the thyroarytenoid muscles using fine-wire electrodes. 1200 pulses of 1 Hz rTMS were delivered to the left LMC in two groups: Control (n = 6) and AdLD (n = 7). Tolerance, adverse effects, intracortical inhibition, and voice recordings were collected immediately before and after rTMS. Voice quality was assessed with acoustic-based and auditory-perceptual measures.

resultsAll participants tolerated the procedures, with no unexpected adverse events or worsening of symptoms. No significant effects on intracortical inhibition were observed. In the AdLD group, there was a large-effect size after rTMS in vocal perturbation measures and a small-effect size in decreased phonatory breaks.

conclusionsOne rTMS session over the LMC is safe and feasible, and demonstrated trends of beneficial effects on voice quality and phonatory function in AdLD. These preliminary findings support further investigation to assess clinical benefits in a future randomized sham-controlled trial. CLINICALTRIALS.GOV: NCT02957942, registered on November 8, 2016.

Indexed as

DystoniaMotor CortexEvoked Potentials, MotorFeasibility StudiesHumansPilot ProjectsTranscranial Magnetic StimulationAcousticsAdductor laryngeal dystoniaCortical silent periodRepetitive transcranial magnetic stimulationSpasmodic dysphonia

Identifiers

PMID34859288
PMCPMC8858301
OpenAlexW3216987341

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.