ArticleBrain communications2021
A novel stroke lesion network mapping approach: improved accuracy yet still low deficit prediction.
Article in Brain communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Considering biological limitations of lesion network mapping.Nature neuroscience · 2026Article
- Cognition disconnected: the influence of domain-general cognition (g) in lesion-deficit mapping.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- A clinical neuroimaging platform for rapid, automated lesion detection and personalized post-stroke outcome prediction.NPJ digital medicine · 2026Article
- A peri-tumoral TREM2-high myeloid state, myeloid continuum polarization, and white matter disconnection in long-term cognitive survivorship after diffuse glioma: a neuroimmune-connectomic cohort study.Frontiers in immunology · 2026Article
- Cognition Disconnected: The Influence of Domain-General Cognition (g) in Lesion-Deficit Mapping.bioRxiv : the preprint server for biology · 2025Article
- Reduced mind-wandering and fewer depressive symptoms associated with damage to the medial prefrontal cortex and default mode network.Neuropsychologia · 2025Article
- Acute Stroke Severity Assessment: The Impact of Lesion Size and Functional Connectivity.Brain sciences · 2025Article
- Dorsomedial and ventromedial prefrontal cortex lesions differentially impact social influence and temporal discounting.PLoS biology · 2025Article
- Large-scale network topography of stroke predicts functional outcome after mechanical thrombectomy.Brain communications · 2025Article
- Enhancing cognitive performance prediction by white matter hyperintensity connectivity assessment.Brain : a journal of neurology · 2024Article
- Heterogenous brain activations across individuals localize to a common network.Communications biology · 2024Article
- Enhancing Cognitive Performance Prediction through White Matter Hyperintensity Connectivity Assessment: A Multicenter Lesion Network Mapping Analysis of 3,485 Memory Clinic Patients.medRxiv : the preprint server for health sciences · 2024Article
- Article
- Using predictive validity to compare associations between brain damage and behavior.Human brain mapping · 2023Article
- Large-scale lesion symptom mapping of depression identifies brain regions for risk and resilience.Brain : a journal of neurology · 2023Article
- Associations of lesion location, structural disconnection, and functional diaschisis with depressive symptoms post stroke.Frontiers in neurology · 2023Article
- Functional and structural lesion network mapping in neurological and psychiatric disorders: a systematic review.Frontiers in neurology · 2023Article
- Multimodal and multidomain lesion network mapping enhances prediction of sensorimotor behavior in stroke patients.Scientific reports · 2022Article
- Mapping lesion, structural disconnection, and functional disconnection to symptoms in semantic aphasia.Brain structure & function · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lesion network mapping estimates functional network abnormalities caused by a focal brain lesion. The method requires embedding the volume of the lesion into a normative functional connectome and using the average functional magnetic resonance imaging signal from that volume to compute the temporal correlation with all other brain locations. Lesion network mapping yields a map of potentially functionally disconnected regions. Although promising, this approach does not predict behavioural deficits well. We modified lesion network mapping by using the first principal component of the functional magnetic resonance imaging signal computed from the voxels within the lesioned area for temporal correlation. We measured potential improvements in connectivity strength, anatomical specificity of the lesioned network and behavioural prediction in a large cohort of first-time stroke patients at 2-weeks post-injury (
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