Evidence map›Paper›PMID 34859113›Full record

ArticleOpen forum infectious diseases2021

Impact of Choice of Prophylaxis on the Microbiology of Cardiac Implantable Electronic Device Infections: Insights From the Prevention of Arrhythmia Device Infection Trial (PADIT).

Yves Longtin, Philippe Gervais, David H Birnie, Jia Wang, Marco Alings, François Philippon, Ratika Parkash, Jaimie Manlucu, Paul Angaran, Claus Rinne and 23 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Open forum infectious diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01002911 (Phase III Pilot Study - A Simple Randomized Trial of Conventional Versus Multimodal Prevention of Arrhythmia Device Infection), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01002911 phase3completednot on this map

Phase III Pilot Study - A Simple Randomized Trial of Conventional Versus Multimodal Prevention of Arrhythmia Device Infection

TypeinterventionalSponsorPopulation Health Research InstituteRan2009 to 2012Enrolled500ConditionsArrythmiasArmsCefazolin, Bacitracin, Cefalexin, Cefazolin
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Microbiology of cardiac implantable electronic device infections in Calgary, Canada.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2024
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors at 20 institutions in 2 countries.

Yves LongtinJewish General Hospital Sir Mortimer B. Davis, McGill University, Montreal, Quebec, Canada.
Philippe GervaisInstitut universitaire de cardiologie et de pneumologie de Québec, Laval University, Quebec City, Quebec, Canada.
David H BirnieUniversity of Ottawa Heart Institute, Ottawa, Ontario, Canada.
Jia WangPopulation Health Research Institute, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada.
Marco AlingsAmphia Ziekenhuis & Working Group on Cardiovascular Research (WCN), Breda, the Netherlands.ORCID https://orcid.org/0000-0003-2090-4683
François PhilipponInstitut universitaire de cardiologie et de pneumologie de Québec, Laval University, Quebec City, Quebec, Canada.ORCID https://orcid.org/0000-0002-2012-0486
Ratika ParkashQueen Elizabeth II Health Science Center, Halifax, Nova Scotia, Canada.
Jaimie ManlucuLawson Health Research Institute, London Health Sciences, Western University, London, Ontario, Canada.
Paul AngaranDepartment of Medicine, University of Toronto, Division of Cardiology, St. Michael's Hospital, Toronto, Ontario, Canada.ORCID https://orcid.org/0000-0003-2697-173X
Claus RinneSt. Mary's General Hospital, Kitchener, Ontario, Canada.
Benoit CoutuCentre hospitalier de l'Université de Montréal (CHUM), University of Montreal, Montreal, Quebec, Canada.
R Aaron LowChinook Regional Hospital, Lethbridge, Alberta, Canada.
Vidal EssebagMcGill University Health Center, Montreal, Quebec, Canada.ORCID https://orcid.org/0000-0003-0107-5197
Carlos MorilloPopulation Health Research Institute, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada.
Damian RedfearnKingston General Hospital, Queen's University, Kingston, Ontario, Canada.
Satish ToalHorizon Health Network, Saint John, New Brunswick, Canada.
Giuliano BeckerHôpital du Sacré-Coeur de Montréal, University of Montreal, Montreal, Quebec, Canada.
Michel DegrâceHôtel-Dieu de Lévis, Lévis, Quebec, Canada.
Bernard ThibaultMontreal Heart Institute, Montreal, Quebec, Canada.
Eugene CrystalSunnybrook Health Sciences Centre, Toronto, Ontario, Canada.ORCID https://orcid.org/0000-0002-1723-6154
Stanley TungSt. Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
John LeMaitreRoyal Columbian Hospital, New Westminster, British Columbia, Canada.
Omar SultanRegina General Hospital, Saskatchewan Health Authority, Regina, Saskatchewan, Canada.
Matthew BennettUniversity of British Columbia, Vancouver, British Columbia, Canada.ORCID https://orcid.org/0000-0002-1675-8225
Jamil BashirSt. Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
Felix Ayala-ParedesCentre Hospitalier Universitaire de Sherbrooke (CHUS), Sherbrooke, Quebec, Canada.
Leon RiouxCentre de santé et de services sociaux de Rimouski-Neigette (CSSSRN), Rimouski, Quebec, Canada.
Martin E W HemelsZiekenhuis Rijnstate, Arnhem, and Radboud University Medical Centre, Nijmegen, the Netherlands.
Leon H R BouwelsCanisius Wilhelmina Ziekenhuis, Nijmegen, the Netherlands.
Derek V ExnerLibin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada.ORCID https://orcid.org/0000-0003-2099-0083
Paul DorianDepartment of Medicine, University of Toronto, Division of Cardiology, St. Michael Hospital, Toronto, Ontario, Canada.
Stuart J ConnollyPopulation Health Research Institute, Hamilton Health Sciences, McMaster University, Hamilton, Ontario, Canada.
Andrew D KrahnUniversity of British Columbia, Vancouver, British Columbia, Canada.
University of British Columbia · CAPopulation Health Research Institute · CAInstitut universitaire de cardiologie et de pneumologie de Québec · CASt. Michael's Hospital · CAAmphia Ziekenhuis · NLCanisius-Wilhelmina Ziekenhuis · NLCégep de Lévis · CACentre Hospitalier de l’Université de Montréal · CACentre Hospitalier Universitaire de Sherbrooke · CACentre Intégré de Santé et de Services Sociaux du Bas-Saint-Laurent · CAChinook Regional Hospital · CAHôpital du Sacré-Cœur de Montréal · CAHorizon Health Network · CAJewish General Hospital · CAMcGill University Health Centre · CAMontreal Heart Institute · CAQueen Elizabeth II Health Sciences Centre · CAQueen's University · CARadboud University Nijmegen · NLRoyal Columbian Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe Prevention of Arrhythmia Device Infection Trial (PADIT) investigated whether intensification of perioperative prophylaxis could prevent cardiac implantable electronic device (CIED) infections. Compared with a single dose of cefazolin, the perioperative administration of cefazolin, vancomycin, bacitracin, and cephalexin did not significantly decrease the risk of infection. Our objective was to compare the microbiology of infections between study arms in PADIT.

methodsThis was a post hoc analysis. Differences between study arms in the microbiology of infections were assessed at the level of individual patients and at the level of microorganisms using the Fisher exact test.

resultsOverall, 209 microorganisms were reported from 177 patients. The most common microorganisms were coagulase-negative staphylococci (CoNS; 82/209 [39.2%]) and

conclusionsIntensification of the prophylaxis led to significant changes in the microbiology of infections, despite the absence of a decrease in the overall risk of infections. These findings provide important insight on the physiopathology of CIED infections.

trial registrationNCT01002911.

Indexed as

cardiac electronic implantable deviceinfectionmicrobiologypreventionprophylaxis

Identifiers

PMID34859113
PMCPMC8632784
OpenAlexW3207489244

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.