ArticleFrontiers in cardiovascular medicine2021
Shared Genetic Liability and Causal Associations Between Major Depressive Disorder and Cardiovascular Diseases.
Article in Frontiers in cardiovascular medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Identification ofDepression and anxiety · 2025Pooled it
- Associations between sleep duration and cardiovascular diseases: A meta-review and meta-analysis of observational and Mendelian randomization studies.Frontiers in cardiovascular medicine · 2022Pooled it
- Causal Association and Shared Genetics Between Asthma and COVID-19.Frontiers in immunology · 2022Pooled it
- Genetic perspectives on the comorbidity of anxiety and mood disorders with cardiovascular disease.Nature cardiovascular research · 2026Review
- Familial coaggregation and shared genetic loading of mental disorders and cardiovascular diseases.Psychological medicine · 2026Article
- Health Insurance as a Moderator of Cardiovascular Risk Among Adults with Depression: A Cross-Sectional and Geographic Analysis Using BRFSS 2019-2023 Data.Healthcare (Basel, Switzerland) · 2026Article
- Genetic susceptibility to depression and risk of cardiometabolic diseases: a systematic review and meta-analysis of 21 Mendelian randomisation studies.EClinicalMedicine · 2025Article
- Identifying Cardiovascular Disease Risk Endotypes of Adolescent Major Depressive Disorder Using Exploratory Unsupervised Machine Learning.JAACAP open · 2025Article
- Exploring the Relationship Between Heart, Brain, and Depression.Medical archives (Sarajevo, Bosnia and Herzegovina) · 2025Review
- Review
- Phenome-wide investigation of bidirectional causal relationships between major depressive disorder and common human diseases.Translational psychiatry · 2024Article
- Sex-Specific Association Between Genetic Risk of Psychiatric Disorders and Cardiovascular Diseases.Circulation. Genomic and precision medicine · 2024Article
- Associations between daytime napping, sleep duration, and depression and 15 cardiovascular diseases: a Mendelian randomization study.Cardiovascular diagnosis and therapy · 2024Article
- Perinatal depression and risk of maternal cardiovascular disease: a Swedish nationwide study.European heart journal · 2024Article
- Distinct biological signature and modifiable risk factors underlie the comorbidity between major depressive disorder and cardiovascular disease.Nature cardiovascular research · 2024Article
- Bidirectional associations between mental disorders, antidepressants and cardiovascular disease.BMJ mental health · 2024Article
- Distinct genomic signatures and modifiable risk factors underly the comorbidity between major depressive disorder and cardiovascular disease.medRxiv : the preprint server for health sciences · 2024Article
- Global epidemiology of mental disorder in atrial fibrillation between 1998-2021: A systematic review and meta-analysis.World journal of psychiatry · 2024Article
- Causal associations between hand grip strength and pulmonary function: a two-sample Mendelian randomization study.BMC pulmonary medicine · 2023Article
- Depression and associated factors among Brazilian adults: the 2019 national healthcare population-based study.BMC psychiatry · 2023Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Major depressive disorder (MDD) is phenotypically associated with cardiovascular diseases (CVD). We aim to investigate mechanisms underlying relationships between MDD and CVD in the context of shared genetic variations. Polygenic overlap analysis was used to test genetic correlation and to analyze shared genetic variations between MDD and seven cardiovascular outcomes (coronary artery disease (CAD), heart failure, atrial fibrillation, stroke, systolic blood pressure, diastolic blood pressure, and pulse pressure measurement). Mendelian randomization analysis was used to uncover causal relationships between MDD and cardiovascular traits. By cross-trait meta-analysis, we identified a set of genomic loci shared between the traits of MDD and stroke. Putative causal genes for MDD and stroke were prioritized by fine-mapping of transcriptome-wide associations. Polygenic overlap analysis pointed toward substantial genetic variation overlap between MDD and CVD. Mendelian randomization analysis indicated that genetic liability to MDD has a causal effect on CAD and stroke. Comparison of genome-wide genes shared by MDD and CVD suggests 20q12 as a pleiotropic region conferring risk for both MDD and CVD. Cross-trait meta-analyses and fine-mapping of transcriptome-wide association signals identified novel risk genes for MDD and stroke, including
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.