ArticleFrontiers in chemistry2021
Green Fabrication and Release Mechanisms of pH-Sensitive Chitosan-Ibuprofen Aerogels for Controlled Transdermal Delivery of Ibuprofen.
Article in Frontiers in chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Article
- Predicting the formation of NADES using a transformer-based model.Scientific reports · 2024Article
- Composite Hydrogels with Embedded Silver Nanoparticles and Ibuprofen as Wound Dressing.Gels (Basel, Switzerland) · 2023Article
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Authors and funding
3 authors.
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Abstract
Ibuprofen is a potent non-steroidal anti-inflammatory drug due to its analgesic, antipyretic, and anti-inflammatory actions. However, its poor solubility in water makes it difficult to manufacture ibuprofen tablets, which limited the application of ibuprofen in drug delivery systems. Polymer-drug aerogels have attracted huge interest in optimizing the drug delivery efficiency and improving the physicochemical characteristics and therapeutic quality. Here, chitosan-ibuprofen aerogels with excellent swelling, high biocompatibility, and better drug delivery efficiency were synthesized by a simple method. Our study found that the chitosan-ibuprofen aerogels exhibited remarkably improved thermal stability, excellent swelling ratio, and high drug loading. As a consequence of these favorable properties, the chitosan-ibuprofen aerogels exhibited improved drug delivery efficiency and achieved drug prolonged administration. Our study highlights the great potential of polymer-drug aerogels in improving the drug delivery efficiency of transdermal drug delivery systems.
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