SynthesisFrontiers in oncology2021
Low Ligation Plus High Dissection
Synthesis in Frontiers in oncology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- [Evidence for the extent and oncological benefits of lymphadenectomy in colon and rectal cancer : A narrative review based on meta-analyses].Chirurgie (Heidelberg, Germany) · 2025Pooled it
- Inferior mesenteric artery ligation level in rectal cancer surgery: still no answer-a systematic review and meta-analysis.Langenbeck's archives of surgery · 2023Pooled it
- High Versus Low Ligation of the Inferior Mesenteric Artery in Colorectal Cancer Surgery: A Systematic Review and Meta-Analysis.Medicina (Kaunas, Lithuania) · 2022Pooled it
- Linear versus circular stapler for colorectal anastomosis in laparoscopic sigmoidectomy: a retrospective comparative study.Annals of coloproctology · 2026Article
- Level of Vascular Ligation for Sigmoid Colon Cancer: Does It Matter? The Pina Low-T Study.Journal of surgical oncology · 2026Article
- The clinical effect and oncological results of preserving inferior mesenteric artery during laparoscopic complete mesocolic excision for patients with descending colon cancer: a propensity score-matched analysis.Techniques in coloproctology · 2026Review
- Prognostic Value of Neutrophil-to-Lymphocyte Ratio in Locally Advanced Rectal Cancer Treated with Neoadjuvant Concurrent Chemoradiotherapy and Robotic-Assisted Resection.Oncology research · 2026Article
- Oncologic standards in colon cancer resection: from margins to lymph node yield and mesentery.Frontiers in surgery · 2026Review
- Efficacy and prognosis evaluation of left colic artery preservation in laparoscopic NOSES for rectal cancer: retrospective survival analysis.American journal of cancer research · 2026Article
- Laser speckle contrast imaging for real-time quantification of colonic perfusion following high versus low tie in anterior rectal resection surgery: a pilot prospective study.International journal of surgery (London, England) · 2026Article
- Article
- Comparison of short-term surgical outcomes between high and low tie ligation of the inferior mesenteric artery in robotic rectal cancer surgery: a propensity score matching analysis.Journal of robotic surgery · 2025Article
- Left colic artery-preserving radical rectal cancer surgery: a literature review.Frontiers in surgery · 2025Review
- Short-term outcomes of vessel-oriented D2 and D3 lymph node dissection for sigmoid colon cancer.Techniques in coloproctology · 2024Article
- Article
- To go high, or to go low: the never-ending debate of inferior mesenteric artery ligation.Annals of coloproctology · 2024Article
- Comparison of the short-term and long-term outcomes of three different types of inferior mesenteric artery ligation in left colonic and rectal cancers: a network meta-analysis.Updates in surgery · 2023Review
- Surgical considerations for the "perfect" colorectal anastomosis.Journal of gastrointestinal oncology · 2023Review
- How to prevent postoperative ileus in colorectal surgery? a systematic review.Annals of medicine and surgery (2012) · 2023Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhether high or low ligation of the inferior mesenteric artery (IMA) is superior in surgery for rectal and sigmoid colon cancers remains controversial. Although several meta-analyses have been conducted, the level of lymph node clearance was poorly defined. We performed a meta-analysis comparing high and low ligation of the IMA for sigmoid colon and rectal cancers, with emphasis on high dissection of the lymph node at the IMA root in all the included studies.
methodsPubMed, MEDLINE, and EMBASE databases were searched to identify relevant articles published until 2020. The patient's perioperative and oncologic outcomes were analyzed. Statistical analysis was performed using the statistical software RevMan version 5.4.
resultsA total of 17 studies, including four randomized controlled trials, published between 2011 and 2020 were selected. In total, 1,846 patients received low ligation of the IMA plus high dissection of lymph nodes (LL+HD), and 2,648 patients received high ligation of the IMA (HL). LL+HD was associated with low incidence of anastomotic leakage (
conclusionIn comparison with HL, LL+HD was an effective and safe oncological procedure for sigmoid colon and rectal cancers. Therefore, to ligate the IMA below the level of the left colic artery with D3 high dissection for sigmoid colon and rectal cancers might be suggested once the surgeons are familiar with this technique. SYSTEMATIC REVIEW REGISTRATION: INPLASY.com, identifier 202190029.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.