ArticleBiomedical optics express2021
A scalable, multi-wavelength, broad bandwidth frequency-domain near-infrared spectroscopy platform for real-time quantitative tissue optical imaging.
Article in Biomedical optics express, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Advances in fully integrated wearable near-infrared spectroscopy: hardware innovations and biomedical applications.JPhys photonics · 2026Review
- Multi-layer self-calibrated algorithm for transabdominal fetal pulse oximetry: simulation andJPhys photonics · 2026Article
- Wearable frequency-domain near-infrared spectroscopy (FD-NIRS) system.Biomedical optics express · 2026Article
- Reconfigurable hardware-accelerated, multi-channel, adaptive temperature control platform of VCSELs for high-density fNIRS/DOT.Biomedical optics express · 2025Article
- Towards real-time diffuse optical tomography with a handheld scanning probe.Biomedical optics express · 2025Article
- Broad-Bandwidth Frequency-Domain Near-Infrared Spectroscopy System on a Chip.IEEE sensors journal · 2025Article
- Fundamental effects of array density and modulation frequency on image quality of diffuse optical tomography.Medical physics · 2025Article
- Frequency-domain instrument with custom ASIC for dual-slope near-infrared spectroscopy.The Review of scientific instruments · 2024Article
- Wirelessly Powered Visible Light-Emitting Implant for Surgical Guidance during Lumpectomy.Sensors (Basel, Switzerland) · 2024Article
- Phase-based structured interrogation frequency-domain near-infrared spectroscopy.Journal of the Optical Society of America. A, Optics, image science, and vision · 2024Article
- Cross-wavelength calibrating method for real-time imaging of tissue optical properties using frequency-domain diffuse optical spectroscopy.Biomedical optics express · 2024Article
- Deep learning-enabled high-speed, multi-parameter diffuse optical tomography.Journal of biomedical optics · 2024Article
- Tutorial on methods for estimation of optical absorption and scattering properties of tissue.Journal of biomedical optics · 2024Article
- Reflective optical imaging for scattering medium using chaotic laser.Journal of biomedical optics · 2024Article
- Review of recent advances in frequency-domain near-infrared spectroscopy technologies [Invited].Biomedical optics express · 2023Review
- Design for a low-cost heterodyne frequency domain-diffuse optical spectroscopy system.Biomedical optics express · 2023Article
- System Derived Spatial-Temporal CNN for High-Density fNIRS BCI.IEEE open journal of engineering in medicine and biology · 2023Article
- Multi-modulated frequency domain high density diffuse optical tomography.Biomedical optics express · 2022Article
- Optical imaging and spectroscopy for the study of the human brain: status report.Neurophotonics · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Frequency-domain near-infrared spectroscopy (FD-NIRS) provides quantitative noninvasive measurements of tissue optical absorption and scattering, as well as a safe and accurate method for characterizing tissue composition and metabolism. However, the poor scalability and high complexity of most FD-NIRS systems assembled to date have contributed to its limited clinical impact. To address these shortcomings, we present a scalable, digital-based FD-NIRS platform capable of measuring optical properties and tissue chromophore concentrations in real-time. The system provides single-channel FD-NIRS amplitude/phase, optical property, and chromophore data at a maximum display rate of 36.6 kHz, 17.9 kHz, and 10.2 kHz, respectively, and can be scaled to multiple channels as well as integrated into a handheld format. The entire system is enabled by several innovations including an ultra-high-speed k-nearest neighbor lookup table method (maximum of 250,000 inversions/s for a large 2500x700 table of absorption and reduced scattering coefficients), embedded FPGA and CPU high-speed co-processing, and high-speed data transfer (due to on-board processing). We show that our 6-wavelength, broad modulation bandwidth (1-400 MHz) system can be used to perform 2D high-density spatial mapping of optical properties and high speed quantification of hemodynamics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.