Evidence map›Paper›PMID 34858694›Full record

ArticleBiomedical optics express2021

Ultracompact fluorescence smartphone attachment using built-in optics for protoporphyrin-IX quantification in skin.

Brady Hunt, Samuel S Streeter, Alberto J Ruiz, M Shane Chapman, Brian W Pogue

Open access · goldAbstract read
In one paragraph

Article in Biomedical optics express, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Brady HuntThayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA.ORCID https://orcid.org/0000-0002-1143-7668
Samuel S StreeterThayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA.ORCID https://orcid.org/0000-0001-8267-3556
Alberto J RuizThayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA.ORCID https://orcid.org/0000-0002-0577-369X
M Shane ChapmanGeisel School of Medicine, Department of Dermatology, Hanover, New Hampshire 03755, USA.
Brian W PogueThayer School of Engineering, Dartmouth College, Hanover, New Hampshire 03755, USA.ORCID https://orcid.org/0000-0002-9887-670X
Dartmouth College · US

Funding

Small Molecule Enhancers of Photodynamic Therapy for Skin CancerP01CA084203 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI Brian William Pogue · 2001 to 2026
$27.9M
NCI NIH HHS P01 CA084203
6 · The paper itself

Abstract

Smartphone-based fluorescence imaging systems have the potential to provide convenient quantitative image guidance at the point of care. However, common approaches have required the addition of complex optical attachments, which reduce translation potential. In this study, a simple clip-on attachment appropriate for fluorescence imaging of protoporphyrin-IX (PpIX) in skin was designed using the built-in light source and ultrawide camera sensor of a smartphone. Software control for image acquisition and quantitative analysis was developed using the 10-bit video capability of the phone. Optical performance was characterized using PpIX in liquid tissue phantoms and endogenously produced PpIX in mice and human skin. The proposed system achieves a very compact form factor (<30 cm

Identifiers

PMID34858694
PMCPMC8606126
OpenAlexW3205190495

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.