Evidence map›Paper›PMID 34858664›Full record

ArticleCardiology research and practice2021

Incremental Value of Genotype Bins over the HAS-BLED Score for the Prediction of Bleeding Risk in Warfarin-Treated Patients with Atrial Fibrillation.

Jia Liu, Guanyun Wang, Liu'an Qin, Yangxun Wu, Yuting Zou, Xuyun Wang, Ziqian Wang, Yuyan Wang, Shizhao Zhang, Yuxiao Zhang and 1 more

Open access · goldAbstract read
In one paragraph

Article in Cardiology research and practice, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Prevalence of risk phenotypes associated withFrontiers in pharmacology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Jia LiuInstitute of Geriatrics, National Clinical Research Center for Geriatric Diseases, 2 Medical Center, Medical School of Chinese PLA and Chinese PLA General Hospital, Beijing 10053, China.ORCID https://orcid.org/0000-0003-4414-9723
Guanyun WangInstitute of Geriatrics, National Clinical Research Center for Geriatric Diseases, 2 Medical Center, Medical School of Chinese PLA and Chinese PLA General Hospital, Beijing 10053, China.ORCID https://orcid.org/0000-0003-1880-7163
Liu'an QinInstitute of Geriatrics, National Clinical Research Center for Geriatric Diseases, 2 Medical Center, Medical School of Chinese PLA and Chinese PLA General Hospital, Beijing 10053, China.ORCID https://orcid.org/0000-0003-4897-2928
Yangxun WuInstitute of Geriatrics, National Clinical Research Center for Geriatric Diseases, 2 Medical Center, Medical School of Chinese PLA and Chinese PLA General Hospital, Beijing 10053, China.ORCID https://orcid.org/0000-0002-7836-5507
Yuting ZouInstitute of Geriatrics, National Clinical Research Center for Geriatric Diseases, 2 Medical Center, Medical School of Chinese PLA and Chinese PLA General Hospital, Beijing 10053, China.ORCID https://orcid.org/0000-0003-0720-6645
Xuyun WangDepartment of Cardiology, 1 Medical Center, Medical School of Chinese PLA, Beijing 10053, China.ORCID https://orcid.org/0000-0002-7968-0525
Ziqian WangInstitute of Geriatrics, National Clinical Research Center for Geriatric Diseases, 2 Medical Center, Medical School of Chinese PLA and Chinese PLA General Hospital, Beijing 10053, China.ORCID https://orcid.org/0000-0002-6996-4356
Yuyan WangInstitute of Geriatrics, National Clinical Research Center for Geriatric Diseases, 2 Medical Center, Medical School of Chinese PLA and Chinese PLA General Hospital, Beijing 10053, China.ORCID https://orcid.org/0000-0002-0207-6995
Shizhao ZhangInstitute of Geriatrics, National Clinical Research Center for Geriatric Diseases, 2 Medical Center, Medical School of Chinese PLA and Chinese PLA General Hospital, Beijing 10053, China.ORCID https://orcid.org/0000-0001-7594-2113
Yuxiao ZhangDepartment of Cardiology, 1 Medical Center, Medical School of Chinese PLA, Beijing 10053, China.ORCID https://orcid.org/0000-0002-7781-6716
Tong YinInstitute of Geriatrics, National Clinical Research Center for Geriatric Diseases, 2 Medical Center, Medical School of Chinese PLA and Chinese PLA General Hospital, Beijing 10053, China.ORCID https://orcid.org/0000-0002-3399-7092
Chinese PLA General Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study aimed to analyse the role of the HAS-BLED score with the addition of genotype bins for bleeding risk prediction in warfarin-treated patients with atrial fibrillation (AF). METHODS AND

resultsConsecutive patients with AF on initial warfarin treatment were recruited. For each patient, CYP2C9

conclusionsGenotypes have an incremental predictive value when combined with the HAS-BLED score for the prediction of clinically relevant bleeding in warfarin-treated patients with AF.

Identifiers

PMID34858664
PMCPMC8632379
OpenAlexW3215853246

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.