Evidence map›Paper›PMID 34858548›Full record

ArticleNutrition research and practice2021

Schisandrae Fructus ethanol extract attenuates particulate matter 2.5-induced inflammatory and oxidative responses by blocking the activation of the ROS-dependent NF-κB signaling pathway.

Hyesook Lee, Cheol Park, Da Hye Kwon, Hyun Hwangbo, So Young Kim, Min Yeong Kim, Seon Yeong Ji, Da Hye Kim, Jin-Woo Jeong, Gi-Young Kim and 2 more

Open access · diamondAbstract read
In one paragraph

Article in Nutrition research and practice, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Chitosan Nanoparticle-EncapsulatedInternational journal of molecular sciences · 2025
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  3. Review
  4. A Mixture ofJournal of microbiology and biotechnology · 2023
    Article
  5. Article
  6. Article
  7. An analysis of the nutritional effects ofFrontiers in nutrition · 2023
    Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Hyesook LeeAnti-Aging Research Center, Dong-Eui University, Busan 47340, Korea.ORCID https://orcid.org/0000-0003-3546-9370
Cheol ParkDivision of Basic Sciences, College of Liberal Studies, Dong-Eui University, Busan 47340, Korea.ORCID https://orcid.org/0000-0003-4906-0410
Da Hye KwonAnti-Aging Research Center, Dong-Eui University, Busan 47340, Korea.ORCID https://orcid.org/0000-0001-5492-7184
Hyun HwangboAnti-Aging Research Center, Dong-Eui University, Busan 47340, Korea.ORCID https://orcid.org/0000-0003-2180-1205
So Young KimAnti-Aging Research Center, Dong-Eui University, Busan 47340, Korea.ORCID https://orcid.org/0000-0002-3238-6900
Min Yeong KimAnti-Aging Research Center, Dong-Eui University, Busan 47340, Korea.ORCID https://orcid.org/0000-0001-9083-8218
Seon Yeong JiAnti-Aging Research Center, Dong-Eui University, Busan 47340, Korea.ORCID https://orcid.org/0000-0001-8564-8663
Da Hye KimAnti-Aging Research Center, Dong-Eui University, Busan 47340, Korea.ORCID https://orcid.org/0000-0002-0846-0357
Jin-Woo JeongNakdonggang National Institute of Biological Resources, Sangju 37242, Korea.ORCID https://orcid.org/0000-0002-7549-4514
Gi-Young KimDepartment of Marine Life Sciences, Jeju National University, Jeju 63243, Korea.ORCID 0000-0002-6878-0790
Hye-Jin HwangDepartment of Food and Nutrition, Dong-Eui University, Busan 47340, Korea.ORCID 0000-0002-5448-6443
Yung Hyun ChoiAnti-Aging Research Center, Dong-Eui University, Busan 47340, Korea.ORCID https://orcid.org/0000-0002-1454-3124
Dong-Eui University · KRJeju National University · KRNational Institute of Biological Resources · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesSchisandrae Fructus, the fruit of MATERIALS/

methodsTo investigate the anti-inflammatory and antioxidant effects of SF in PM2.5-stimulated RAW 264.7 cells, the levels of pro-inflammatory mediator such as nitric oxide (NO) and prostaglandin E

resultsThe results indicated that SF treatment significantly inhibited the PM2.5-induced release of NO and PGE

conclusionsOur findings suggest that SF exerts anti-inflammatory and antioxidant effects against PM2.5 through ROS-dependent down-regulating the NF-κB signaling pathway, and that SF can be a potential functional substance to prevent PM2.5-mediated inflammatory and oxidative damage.

Indexed as

inflammationNF-kappa Boxidative stressParticulate matterreactive oxygen species

Identifiers

PMID34858548
PMCPMC8601940
OpenAlexW3162430362

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.