Evidence map›Paper›PMID 34858437›Full record

ArticleFrontiers in immunology2021

Differential Signature of the Microbiome and Neutrophils in the Oral Cavity of HIV-Infected Individuals.

Eliana Perez Rosero, Samantha Heron, Juan Jovel, Conar R O'Neil, Shannon Lee Turvey, Pallavi Parashar, Shokrollah Elahi

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Dysbiosis modulates CD8iScience · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Oral Cells-On-Chip: Design, Modeling and Experimental Results.Bioengineering (Basel, Switzerland) · 2022
    Article
  16. Hematopoietic responses to SARS-CoV-2 infection.Cellular and molecular life sciences : CMLS · 2022
    Review
  17. Article
  18. Article
  19. [Immunological Causes of Oral Manifestations of HIV Infection: A Literature Review].Revista cientifica odontologica (Universidad Cientifica del Sur)
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Eliana Perez RoseroDepartment of Dentistry, University of Alberta, Edmonton, AB, Canada.
Samantha HeronDepartment of Dentistry, University of Alberta, Edmonton, AB, Canada.
Juan JovelDepartment of Dentistry, University of Alberta, Edmonton, AB, Canada.
Conar R O'NeilDepartment of Medicine, Division of Infectious Disease, University of Alberta, Edmonton, AB, Canada.
Shannon Lee TurveyDepartment of Medicine, Division of Infectious Disease, University of Alberta, Edmonton, AB, Canada.
Pallavi ParasharDepartment of Dentistry, University of Alberta, Edmonton, AB, Canada.
Shokrollah ElahiDepartment of Dentistry, University of Alberta, Edmonton, AB, Canada.
University of Alberta · CA

Funding

CIHR
6 · The paper itself

Abstract

HIV infection is associated with a wide range of changes in microbial communities and immune cell components of the oral cavity. The purpose of this study was to evaluate the oral microbiome in relationship to oral neutrophils in HIV-infected compared to healthy individuals. We evaluated oral washes and saliva samples from HIV-infected individuals (n=52) and healthy controls (n=43). Using 16S-rRNA gene sequencing, we found differential β-diversity using Principal Coordinate Analysis (PCoA) with Bray-Curtis distances. The α-diversity analysis by Faith's, Shannon, and observed OTUs indexes indicated that the saliva samples from HIV-infected individuals harbored significantly richer bacterial communities compared to the saliva samples from healthy individuals. Notably, we observed that five species of Spirochaeta including

Indexed as

HIV InfectionsHumansMicrobiotaMouthNeutrophilsSalivaCD44galectin-9HIV infectionneutrophilsoral microbiome

Identifiers

PMID34858437
PMCPMC8630784
OpenAlexW3212880719

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.