Evidence map›Paper›PMID 34858396›Full record

ArticleFrontiers in immunology2021

Rapid Assessment of Binding Affinity of SARS-COV-2 Spike Protein to the Human Angiotensin-Converting Enzyme 2 Receptor and to Neutralizing Biomolecules Based on Computer Simulations.

Damiano Buratto, Abhishek Saxena, Qun Ji, Guang Yang, Sergio Pantano, Francesco Zonta

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Damiano BurattoShanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China.
Abhishek SaxenaShanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China.
Qun JiShanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China.
Guang YangShanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China.
Sergio PantanoShanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China.
Francesco ZontaShanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China.
ShanghaiTech University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

SARS-CoV-2 infects humans and causes Coronavirus disease 2019 (COVID-19). The S1 domain of the spike glycoprotein of SARS-CoV-2 binds to human angiotensin-converting enzyme 2 (hACE2)

Indexed as

Angiotensin-Converting Enzyme 2Computer SimulationMolecular Dynamics SimulationAntibodies, NeutralizingAntibody AffinityHumansMutationSARS-CoV-2Spike Glycoprotein, CoronavirusACE2 protein, humanAngiotensin-Converting Enzyme 2Antibodies, NeutralizingSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2binding affinityCOVID-19human ACE2molecular dynamicsneutralizing antibodiesprotein-protein interactionSARS-CoV-2Spike-RBD

Identifiers

PMID34858396
PMCPMC8632240
OpenAlexW3213529457

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.