Evidence map›Paper›PMID 34858342›Full record

ReviewFrontiers in endocrinology2021

miRNA, lncRNA and circRNA: Targeted Molecules Full of Therapeutic Prospects in the Development of Diabetic Retinopathy.

Xingyu Chang, Guomao Zhu, Zongyan Cai, Yaqi Wang, Rongna Lian, Xulei Tang, Chengxu Ma, Songbo Fu

Abstract readReview
In one paragraph

Review in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Review
  2. Article
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  7. Article
  8. Curcumol ameliorates diabetic retinopathyWorld journal of diabetes · 2025
    Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. The mFrontiers in endocrinology · 2024
    Review
  17. Article
  18. Review
  19. Potential Diagnostic Markers of Diabetic Retinopathy: Serum LncRNA MIAT, HOTTIP, SNHG16.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xingyu ChangThe First Clinical Medical College, Lanzhou University, Lanzhou, China.
Guomao ZhuThe First Clinical Medical College, Lanzhou University, Lanzhou, China.
Zongyan CaiThe Second Clinical Medical College, Lanzhou University, Lanzhou, China.
Yaqi WangThe First Clinical Medical College, Lanzhou University, Lanzhou, China.
Rongna LianThe First Clinical Medical College, Lanzhou University, Lanzhou, China.
Xulei TangThe First Clinical Medical College, Lanzhou University, Lanzhou, China.
Chengxu MaThe First Clinical Medical College, Lanzhou University, Lanzhou, China.
Songbo FuThe First Clinical Medical College, Lanzhou University, Lanzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic retinopathy (DR) is a common diabetic complication and the main cause of blindness worldwide, which seriously affects the quality of life of patients. Studies have shown that noncoding RNA (ncRNA) has distinct differentiated expression in DR and plays an important role in the occurrence and development of DR. ncRNAs represented by microRNAs (miRNAs), lncRNAs (lncRNAs), and circRNAs (circRNAs) have been shown to be widely involved in the regulation of gene expression and affect multiple biological processes of retinopathy. This article will review three RNAs related to the occurrence and development of DR on the basis of previous studies (especially their effects on retinal microangiopathy, retinal pigment epithelial cells, and retinal nerve cells) and discuss their underlying mechanisms and connections. Overall, this review will help us better understand the role of ncRNAs in the occurrence and development of DR and provide ideas for exploring potential therapeutic directions and targets.

Indexed as

AnimalsDiabetic RetinopathyGene Expression RegulationHumansMicroRNAsRNA, CircularRNA, Long NoncodingMicroRNAsRNA, CircularRNA, Long NoncodingcircRNAdiabetesdiabetic retinopathylncRNAmiRNA

Identifiers

PMID34858342
PMCPMC8631471

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.