ArticleFrontiers in endocrinology2021
Use of Induced Pluripotent Stem Cells to Build Isogenic Systems and Investigate Type 1 Diabetes.
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Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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0cells of the map it votes in
16citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
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Who cites it
16 citing papers in PubMed, 18 citations in OpenAlex.
- LPS stimulation reveals male and female dimorphism in human iPSC-derived macrophages.iScience · 2026Article
- Type 1 diabetesNPJ autoimmunity · 2026Article
- Application potential of induced pluripotent stem cells in the research and treatment of autoimmune diseases (Review).Molecular medicine reports · 2025Review
- Review
- Type 1 Diabetes: A Guide to Autoimmune Mechanisms for Clinicians.Diabetes, obesity & metabolism · 2025Review
- Closing the Gap Between Vision and Victory in Type 1 Diabetes: The NIDDK Human Islet Research Network (HIRN) Initiative.Diabetes · 2025Review
- Peptide-Coated Polycaprolactone-Benzalkonium Chloride Nanocapsules for Targeted Drug Delivery to the Pancreatic β-Cell.ACS applied bio materials · 2024Article
- Untangling the genetics of beta cell dysfunction and death in type 1 diabetes.Molecular metabolism · 2024Review
- Macrophages enhance contractile force in iPSC-derived human engineered cardiac tissue.Cell reports · 2024Article
- Histone demethylase JARID1C/KDM5C regulates Th17 cells by increasing IL-6 expression in diabetic plasmacytoid dendritic cells.JCI insight · 2024Article
- Research progress of autoimmune diseases based on induced pluripotent stem cells.Frontiers in immunology · 2024Review
- Insulin-like Growth Factor-1 Synergizes with IL-2 to Induce Homeostatic Proliferation of Regulatory T Cells.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- Modeling cell-mediated immunity in human type 1 diabetes by engineering autoreactive CD8Frontiers in immunology · 2023Article
- Stem Cell-Derived β Cells: A Versatile Research Platform to Interrogate the Genetic Basis of β Cell Dysfunction.International journal of molecular sciences · 2022Review
- Review
- The Foundation for Engineering a Pancreatic Islet Niche.Frontiers in endocrinology · 2022Review
Corrections and comments
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Authors and funding
21 authors at 4 institutions in 1 country.
Lucas H ArmitageDepartment of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, United States.
Scott E StimpsonDepartment of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, United States.
Katherine E SantostefanoDepartment of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, United States.
Lina SuiDepartment of Pediatrics, Naomi Berrie Diabetes Center, Columbia Stem Cell Initiative, Columbia University, New York, NY, United States.
Similoluwa OgundareDepartment of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, United States.
Brittney N NewbyDepartment of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, United States.
Roberto Castro-GutierrezBarbara Davis Center for Diabetes, University of Colorado School of Medicine, Aurora, CO, United States.
Mollie K HuberDepartment of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, United States.
Jared P TaylorDepartment of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, United States.
Prerana SharmaChildren's Health Research Center, Sanford Research, Sioux Falls, SD, United States.
Ilian A RadichevChildren's Health Research Center, Sanford Research, Sioux Falls, SD, United States.
Daniel J PerryDepartment of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, United States.
Natalie C FredetteDepartment of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, United States.
Alexei Y SavinovChildren's Health Research Center, Sanford Research, Sioux Falls, SD, United States.
Mark A WalletDepartment of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, United States.
Naohiro TeradaDepartment of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, United States.
Todd M BruskoDepartment of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, United States.
Holger A RussBarbara Davis Center for Diabetes, University of Colorado School of Medicine, Aurora, CO, United States.
Jing ChenDepartment of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, United States.
Dieter EgliDepartment of Pediatrics, Naomi Berrie Diabetes Center, Columbia Stem Cell Initiative, Columbia University, New York, NY, United States.
Clayton E MathewsDepartment of Pathology, Immunology, and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL, United States.
University of Florida · USSanford Research · USColumbia University · USUniversity of Colorado Denver · US
Funding
Using social networks to map and evaluate team science across CTSA hubsUL1TR001427 · NCATS · UNIVERSITY OF FLORIDA · PI MITCHELL, DUANE A. · 2015 to 2024
$37.2MProject 3P01AI042288 · NIAID · UNIVERSITY OF FLORIDA · PI Todd Michael Brusko · 1997 to 2026
$32.9MUniversity of Colorado Anschutz Medical Campus DRCP30DK116073 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI LORI SUSSEL · 2020 to 2026
$10.8MDetermining the mechanism of IFIH1 disease-associated variants on beta-cell and immune responses in Type 1 diabetesR01DK127497 · NIDDK · UNIVERSITY OF KANSAS MEDICAL CENTER · PI MATHEWS, CLAYTON E, MILLMAN, JEFFREY ROBERT · 2020 to 2023
$4.7MMice with autologous human T1D-derived immune systems and iPSC-derived beta cellsUC4DK104207 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SYKES, MEGAN · 2014 to 2014
$3.8MPredoctoral Training Program in Molecular and Cellular Biology (Supplement: Mentoring in the Research Environment)T32GM136444 · NIGMS · UNIVERSITY OF COLORADO DENVER · PI MICHAEL A MCMURRAY, Rytis Prekeris · 2020 to 2026
$3.7MGenetic Regulation of Human Beta Cell DestructionUC4DK104194 · NIDDK · UNIVERSITY OF FLORIDA · PI MATHEWS, CLAYTON E · 2014 to 2014
$3.1MEngineering a Human Microphysiological System for the Characterization of Islet-Immune InteractionsUH3DK122638 · NIDDK · UNIVERSITY OF FLORIDA · PI AGARWAL, ASHUTOSH, BRUSKO, TODD MICHAEL · 2021 to 2023
$3.0MEngineering a Human Microphysiological System for the Characterization of Islet-Immune InteractionsUG3DK122638 · NIDDK · UNIVERSITY OF FLORIDA · PI AGARWAL, ASHUTOSH, BRUSKO, TODD MICHAEL · 2019 to 2020
$2.1MInterdisciplinary Graduate Program in Type 1 Diabetes and Biomedical EngineeringT32DK108736 · NIDDK · UNIVERSITY OF FLORIDA · PI MARK A. ATKINSON, Benjamin George Keselowsky · 2017 to 2026
$1.9MImmune Response to iPSC-Derived Beta Cells in Type 1 DiabetesR01DK103585 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SYKES, MEGAN · 2015 to 2018
$1.8MPTPN2 mutations affect islet beta cell susceptibility in T1DR01DK125360 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI SUSSEL, LORI · 2020 to 2023
$1.7MNCATS NIH HHS UL1 TR001427NIAID NIH HHS P01 AI042288NIAID NIH HHS R21 AI140044NIDDK NIH HHS F30 DK105788NIDDK NIH HHS P30 DK116073NIDDK NIH HHS R01 DK103585NIDDK NIH HHS R01 DK120444NIDDK NIH HHS R01 DK125360NIDDK NIH HHS R01 DK127497NIDDK NIH HHS T32 DK108736NIDDK NIH HHS UC4 DK104194NIDDK NIH HHS UC4 DK104207NIDDK NIH HHS UH3 DK122638NIGMS NIH HHS R24 GM119977NIGMS NIH HHS T32 GM136444
Abstract
Type 1 diabetes (T1D) is a disease that arises due to complex immunogenetic mechanisms. Key cell-cell interactions involved in the pathogenesis of T1D are activation of autoreactive T cells by dendritic cells (DC), migration of T cells across endothelial cells (EC) lining capillary walls into the islets of Langerhans, interaction of T cells with macrophages in the islets, and killing of β-cells by autoreactive CD8
Indexed as
CD8-Positive T-LymphocytesCell DifferentiationDiabetes Mellitus, Type 1HumansInduced Pluripotent Stem CellsInsulin-Secreting CellsIslets of Langerhansautoimmunitybeta cellshumanimmunityinduced pluripotent stem cellsisogenictype 1 diabetes mellitus
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.