ReviewFrontiers in endocrinology2021
Fibrodysplasia Ossificans Progressiva: What Have We Achieved and Where Are We Now? Follow-up to the 2015 Lorentz Workshop.
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In one paragraph
Review in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 26 citations in OpenAlex.
- Assessing the economic burden and health-related quality of life in chinese patients with fibrodysplasia ossificans progressiva: a questionnaire survey analysis.Orphanet journal of rare diseases · 2025Article
- Challenges in the diagnosis of fibrodysplasia ossificans progressiva with the ACVR1 mutation (c.774G > C, p.R258S): a case report and review of literature.Orphanet journal of rare diseases · 2024Review
- Disturbed glycolipid metabolism activates CXCL13-CXCR5 axis in senescent TSCs to promote heterotopic ossification.Cellular and molecular life sciences : CMLS · 2024Article
- Oxidative phosphorylation is a pivotal therapeutic target of fibrodysplasia ossificans progressiva.Life science alliance · 2024Article
- Mini-invasive video-assisted thyroidectomy vs robot-assisted transaxillary thryoidectomy: analisys and comparison of safety and outcomes.Updates in surgery · 2024Observational
- Performance of simplified methods for quantification of [Frontiers in nuclear medicine · 2024Article
- Fibrodysplasia Ossificans Progressiva Mimics Generalized Dystonia Disorder: A Case Report.Cureus · 2023Article
- Review
- Mast Cell Involvement in the Pathogenesis of Selected Musculoskeletal Diseases.Life (Basel, Switzerland) · 2023Review
- Article
- Novel Therapeutic Targets for Fibrodysplasia Ossificans Progressiva: Emerging Strategies and Future Directions.Cureus · 2023Review
- Intra-abdominal myositis ossificans - a clinically challenging disease: A case report.World journal of orthopedics · 2023Article
- Aggressive atraumatic myositis ossificans in a toddler.Radiology case reports · 2022Article
- A Systematic Review of the Evidence of Hematopoietic Stem Cell Differentiation to Fibroblasts.Biomedicines · 2022Review
- Gene Therapy for Fibrodysplasia Ossificans Progressiva: Feasibility and Obstacles.Human gene therapy · 2022Review
- SARS-CoV-2-specific humoral and cellular immune responses to BNT162b2 vaccine in Fibrodysplasia ossificans progressiva patients.Frontiers in immunology · 2022Article
- Monitoring and Management of Fibrodysplasia Ossificans Progressiva: Current Perspectives.Orthopedic research and reviews · 2022Review
- Editorial: Innovative Models in Bone Biology: What can be Learned From Rare Bone Diseases?Frontiers in endocrinology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
35 authors at 20 institutions in 10 countries.
Ruben D de RuiterDepartment of Internal Medicine, Section Endocrinology, Amsterdam University Medical Center (Amsterdam UMC), Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, Netherlands.
Bernard J SmildeDepartment of Internal Medicine, Section Endocrinology, Amsterdam University Medical Center (Amsterdam UMC), Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, Netherlands.
Gerard PalsDepartment of Clinical Genetics and Bone Histomorphology, Amsterdam University Medical Center (Amsterdam UMC), Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Nathalie BravenboerDepartment of Clinical Chemistry, Amsterdam University Medical Center (Amsterdam UMC), Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, Netherlands.
Petra KnausFreie Universität Berlin, Institute for Chemistry and Biochemistry, Berlin, Germany.
Ton SchoenmakerDepartment of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit, Amsterdam, Netherlands.
Esmée BotmanDepartment of Internal Medicine, Section Endocrinology, Amsterdam University Medical Center (Amsterdam UMC), Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, Netherlands.
Gonzalo Sánchez-DuffhuesDepartment of Cell and Chemical Biology, Leiden University Medical Center, Leiden, Netherlands.
Maurizio PacificiTranslational Research Program in Pediatric Orthopaedics, Abramson Research Center, Division of Orthopaedic Surgery, The Children's Hospital of Philadelphia, Philadelphia, PA, United States.
Robert J PignoloDepartment of Medicine, Mayo Clinic, Rochester, MN, United States.
Eileen M ShoreDepartment of Orthopaedic Surgery and Genetics, and the Center for Research in FOP and Related Disorders, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States.
Marjolein van EgmondDepartment of Molecular Cell Biology and Immunology, Cancer Center Amsterdam, Amsterdam University Medical Center (Amsterdam UMC), Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Hans Van OosterwyckDivision of Biomechanics, Department of Mechanical Engineering, Katholieke Universiteit (KU) Leuven, Leuven, Belgium.
Frederick S KaplanDepartment of Orthopaedic Surgery and Medicine, Center for Research in FOP and Related Disorders, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States.
Edward C HsiaoDepartment of Endocrinology and Metabolism, and the Institute for Human Genetics, Department of Medicine, University of California, San Francisco, CA, United States.
Paul B YuDivision of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States.
Renata BocciardiDepartment of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), Università degli Studi di Genova, Medical Genetics Unit, IRCCS Istituto Giannina Gaslini, Genova, Italy.
Carmen Laura De CuntoRheumatology Section, Department of Pediatrics, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina.
Patricia Longo Ribeiro DelaiTeaching and Research Institute of the Hospital Israelita Albert Einstein, Sao Paulo, Brazil.
Teun J de VriesDepartment of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and Vrije Universiteit, Amsterdam, Netherlands.
Susanne HilderbrandtFreie Universität Berlin, Institute for Chemistry and Biochemistry, Berlin, Germany.
Richard T JaspersLaboratory for Myology, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, Netherlands.
Richard KeenCentre for Metabolic Bone Disease, Royal National Orthopaedic Hospital, Stanmore, United Kingdom.
Peter KoolwijkDepartment of Physiology, Amsterdam University Medical Center (Amsterdam UMC), Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Rolf MorhartDepartment of Pediatrics, Garmisch-Partenkichen Medical Center, Garmisch-Partenkirchen, Germany.
Jan C NetelenbosDepartment of Internal Medicine, Section Endocrinology, Amsterdam University Medical Center (Amsterdam UMC), Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, Netherlands.
Thomas RustemeyerDepartment of Dermatology, Amsterdam University Medical Center (AmsterdamUMC), Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Christiaan ScottDivision of Paediatric Rheumatology, Departmet of Paediatrics and Child Heath, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa.
Clemens StockklausnerLaboratory for Myology, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, Netherlands.
Peter Ten DijkeDepartment of Cell and Chemical Biology, Leiden University Medical Center, Leiden, Netherlands.
James TriffitBotnar Research Centre, University of Oxford, Oxford, United Kingdom.
Francesc VenturaDepartamento de Cièncias Fisiológicas, Facultad de Medicina y Ciencias de la Salud, Universitat de Barcelona, Barcelona, Spain.
Roberto RavazzoloDepartment of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), Università degli Studi di Genova, Medical Genetics Unit, IRCCS Istituto Giannina Gaslini, Genova, Italy.
Dimitra MichaDepartment of Clinical Genetics and Bone Histomorphology, Amsterdam University Medical Center (Amsterdam UMC), Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Elisabeth M W EekhoffDepartment of Internal Medicine, Section Endocrinology, Amsterdam University Medical Center (Amsterdam UMC), Vrije Universiteit Amsterdam, Amsterdam Movement Sciences, Amsterdam, Netherlands.
Vrije Universiteit Amsterdam · NLAmsterdam University Medical Centers · NLFreie Universität Berlin · DELeiden University Medical Center · NLUniversity of Pennsylvania · USBrigham and Women's Hospital · USChildren's Hospital of Philadelphia · USGarmisch-Partenkirchen Medical Center · DEHospital Israelita Albert Einstein · BRHospital Italiano de Buenos Aires · ARIstituto Giannina Gaslini · ITKU Leuven · BEMayo Clinic in Arizona · USRed Cross War Memorial Children's Hospital · ZARoyal National Orthopaedic Hospital · GBUniversitat de Barcelona · ESUniversity of Amsterdam · NLUniversity of California, San Francisco · USUniversity of Genoa · ITUniversity of Oxford · GB
Funding
Novel probes of BMP and TGF-beta signaling and functionR01AR057374 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI YU, PAUL B · 2010 to 2023
$4.5MNIAMS NIH HHS R01 AR057374
Abstract
Fibrodysplasia ossificans progressiva (FOP) is an ultra-rare progressive genetic disease effecting one in a million individuals. During their life, patients with FOP progressively develop bone in the soft tissues resulting in increasing immobility and early death. A mutation in the
Indexed as
Myositis OssificansCongresses as TopicEndocrinologyExpert TestimonyHistory, 21st CenturyHumansMutationOssification, Heterotopicangiogenesisdisease modelsfibrodysplasia ossificans progessiva (FOP)inflammationtherapytrials
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.