Evidence map›Paper›PMID 34858208›Full record

ReviewFrontiers in physiology2021

Biocompatible Nanomaterials as an Emerging Technology in Reproductive Health; a Focus on the Male.

Barbara Fraser, Alexandra E Peters, Jessie M Sutherland, Mingtao Liang, Diane Rebourcet, Brett Nixon, Robert J Aitken

Abstract readReview
In one paragraph

Review in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Magnetic nanoparticles as promising materials for the future of medicine.Journal of materials science. Materials in medicine · 2026
    Review
  3. Therapeutic effect ofRSC advances · 2025
    Article
  4. Is Emerging Nanomedicine a Friend or Foe to Germ Cells?International journal of nanomedicine · 2025
    Review
  5. Review
  6. Nanomedicine for Maternal and Fetal Health.Small (Weinheim an der Bergstrasse, Germany) · 2024
    Review
  7. Review
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Barbara FraserPriority Research Centre for Reproductive Science, University of Newcastle, Callaghan, NSW, Australia.
Alexandra E PetersPregnancy and Reproduction Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.
Jessie M SutherlandPregnancy and Reproduction Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.
Mingtao LiangPregnancy and Reproduction Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.
Diane RebourcetPriority Research Centre for Reproductive Science, University of Newcastle, Callaghan, NSW, Australia.
Brett NixonPriority Research Centre for Reproductive Science, University of Newcastle, Callaghan, NSW, Australia.
Robert J AitkenPriority Research Centre for Reproductive Science, University of Newcastle, Callaghan, NSW, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A growing body of research has confirmed that nanoparticle (NP) systems can enhance delivery of therapeutic and imaging agents as well as prevent potentially damaging systemic exposure to these agents by modifying the kinetics of their release. With a wide choice of NP materials possessing different properties and surface modification options with unique targeting agents, bespoke nanosystems have been developed for applications varying from cancer therapeutics and genetic modification to cell imaging. Although there remain many challenges for the clinical application of nanoparticles, including toxicity within the reproductive system, some of these may be overcome with the recent development of biodegradable nanoparticles that offer increased biocompatibility. In recognition of this potential, this review seeks to present recent NP research with a focus on the exciting possibilities posed by the application of biocompatible nanomaterials within the fields of male reproductive medicine, health, and research.

Indexed as

chemotherapyimagingmale reproductive healthnanomaterialsreproductive research

Identifiers

PMID34858208
PMCPMC8632065

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.