Evidence map›Paper›PMID 34858182›Full record

ArticleFrontiers in pharmacology2021

Combination Therapy With Rapamycin and Low Dose Imatinib in Pulmonary Hypertension.

Yinan Shi, Chenxin Gu, Tongtong Zhao, Yangfan Jia, Changlei Bao, Ang Luo, Qiang Guo, Ying Han, Jian Wang, Stephen M Black and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. A Peek into Pulmonary Hypertension through the Plasma Proteome.American journal of respiratory and critical care medicine · 2025
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 2 countries.

Yinan ShiCollege of Veterinary Medicine, Northwest A&F University, Yangling, China.
Chenxin GuCollege of Veterinary Medicine, Northwest A&F University, Yangling, China.
Tongtong ZhaoCollege of Veterinary Medicine, Northwest A&F University, Yangling, China.
Yangfan JiaCollege of Veterinary Medicine, Northwest A&F University, Yangling, China.
Changlei BaoCollege of Veterinary Medicine, Northwest A&F University, Yangling, China.
Ang LuoCollege of Veterinary Medicine, Northwest A&F University, Yangling, China.
Qiang GuoDepartment of Critical Care Medicine, Suzhou Dushu Lake Hospital, The First Affiliated Hospital of Soochow University, Suzhou, China.
Ying HanDepartment of Physiology, Nanjing Medical University, Nanjing, China.
Jian WangState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangdong Key Laboratory of Vascular Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Stephen M BlackDepartment of Cellular Biology and Pharmacology, Herbert Wertheim College of Medicine, Miami, FL, United States.
Ankit A DesaiDepartment of Medicine, Krannert Institute of Cardiology, Indiana University, Indianapolis, IN, United States.
Haiyang TangCollege of Veterinary Medicine, Northwest A&F University, Yangling, China.
Northwest A&F University · CNFlorida International University · USGuangzhou Medical University · CNIndiana University – Purdue University Indianapolis · USNanjing Medical University · CNSoochow University · CNState Key Laboratory of Respiratory Disease · CN

Funding

Pathogenic Role of IL-18 in Sickle Cell Cardiomyopathy and Inducible Ventricular TachycardiaR01HL136603 · NHLBI · UNIVERSITY OF ARIZONA · PI DESAI, ANKIT A · 2017 to 2021
$2.4M
NHLBI NIH HHS R01 HL136603
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

imatinibMTOR signalingPAHPASMCsPDGFRsrapamycin

Identifiers

PMID34858182
PMCPMC8632256
OpenAlexW3213128215

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.