ArticleFrontiers in behavioral neuroscience2021
Spontaneous Visual Preference for Face-Like Stimuli Is Impaired in Newly-Hatched Domestic Chicks Exposed to Valproic Acid During Embryogenesis.
Article in Frontiers in behavioral neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 17 citations in OpenAlex.
- Vocal and social impairments in songbirds embryonically exposed to an autism risk factor.iScience · 2026Article
- Optimizing prenatal valproic acid exposure in zebra finches to model autism-related phenotypes.Psychopharmacology · 2025Article
- Three Decades of Valproate: A Current Model for Studying Autism Spectrum Disorder.Current neuropharmacology · 2024Review
- Face processing in animal models: implications for autism spectrum disorder.Frontiers in neuroscience · 2024Review
- The domestic chick as an animal model of autism spectrum disorder: building adaptive social perceptions through prenatally formed predispositions.Frontiers in neuroscience · 2024Review
- Editorial: Long-lasting neurobehavioral effects of early-life events.Frontiers in neuroscience · 2024Article
- Naïve chicks do not prefer objects with stable body orientation, though they may prefer behavioural variability.Animal cognition · 2023Article
- Do subtle cultural differences sculpt face pareidolia?Schizophrenia (Heidelberg, Germany) · 2023Article
- Face pareidolia in male schizophrenia.Schizophrenia (Heidelberg, Germany) · 2022Article
- Fetal blockade of nicotinic acetylcholine transmission causes autism-like impairment of biological motion preference in the neonatal chick.Cerebral cortex communications · 2022Article
- Avian models for brain mechanisms underlying altered social behavior in autism.Frontiers in physiology · 2022Review
- Embryonic Valproate Exposure Alters Mesencephalic Dopaminergic Neurons Distribution and Septal Dopaminergic Gene Expression in Domestic Chicks.Frontiers in integrative neuroscience · 2022Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Faces convey a great amount of socially relevant information related to emotional and mental states, identity and intention. Processing of face information is a key mechanism for social and cognitive development, such that newborn babies are already tuned to recognize and orient to faces and simple schematic face-like patterns since the first hours of life. Similar to neonates, also non-human primates and domestic chicks have been shown to express orienting responses to faces and schematic face-like patterns. More importantly, existing studies have hypothesized that early disturbances of these mechanisms represent one of the earliest biomarker of social deficits in autism spectrum disorders (ASD). We used VPA exposure to induce neurodevelopmental changes associated with ASD in domestic chicks and tested whether VPA could impact the expression of the animals' approach responses to schematic face-like stimuli. We found that VPA impairs the chicks' preference responses to these social stimuli. Based on the results shown here and on previous studies, we propose the domestic chick as animal model to investigate the biological mechanisms underlying face processing deficits in ASD.
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