ArticleInternational journal of general medicine2021
CD40LG as a Prognostic Molecular Marker Regulates Tumor Microenvironment Through Immune Process in Breast Cancer.
Article in International journal of general medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 19 citations in OpenAlex.
- Inferring Personalized Cell-Cell Communication Networks in Colorectal Cancer with Individualized Causal Discovery.bioRxiv : the preprint server for biology · 2025Article
- Genetic evidence from Mendelian randomization links CD40 levels to increased risk of estrogen receptor-positive breast cancer.Scientific reports · 2025Article
- CircRNA-loaded DC vaccine in combination with low-dose gemcitabine induced potent anti-tumor immunity in pancreatic cancer model.Cancer immunology, immunotherapy : CII · 2025Article
- Establishment of two pathomic-based machine learning models to predict CLCA1 expression in colon adenocarcinoma.PloS one · 2025Article
- Single-cell transcriptomic analysis of canine insulinoma reveals distinct sub-populations of insulin-expressing cancer cells.Veterinary oncology (London, England) · 2025Article
- Construction of a risk model associated with tryptophan metabolism and identification of related molecular subtypes in laryngeal squamous cell carcinoma.Frontiers in genetics · 2025Article
- Pathomics models for CD40LG expression and prognosis prediction in glioblastoma.Scientific reports · 2024Article
- A prospective prognostic signature for pancreatic adenocarcinoma based on ubiquitination-related mRNA-lncRNA with experimental validation in vitro and vivo.Functional & integrative genomics · 2023Article
- Identification of key immune cell-related genes involved in tumorigenesis and prognosis of cervical squamous cell carcinoma.Human vaccines & immunotherapeutics · 2023Article
- BTG2 and SerpinB5, a novel gene pair to evaluate the prognosis of lung adenocarcinoma.Frontiers in immunology · 2023Article
- Comparative Transcriptome Analysis to Investigate the Immunotoxicity Mechanism Triggered by Dimethomorph on Human Jurkat T Cell Lines.Foods (Basel, Switzerland) · 2022Article
- [CD40LG is a novel immune- and stroma-related prognostic biomarker in the tumor microenvironment of invasive breast cancer].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2022Article
- A TP53 Related Immune Prognostic Model for the Prediction of Clinical Outcomes and Therapeutic Responses in Lung Adenocarcinoma.Frontiers in immunology · 2022Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeBreast cancer (BRCA) is the second most common malignancy in the world and the most common in women. Here, we utilized publicly available BRCA dataset to investigate potential prognosis-related genes through integrated bioinformatics analysis. MATERIALS AND
methodsBRCA dataset was obtained from the Cancer Genome Atlas (TCGA) database. The ESTIMATE algorithm was used to calculate the ImmuneScores and StromalScores of the samples and then divided them into high- and low-score groups based on the median score. Common differentially expressed genes (DEGs) were identified through differential expression analysis. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed. The core prognostic genes were the intersection of hub genes from PPI network and prognostic genes from univariate Cox proportional hazard regression analysis. Finally, the CIBERSORT algorithm was used to calculate proportions of 22 tumor-infiltrating immune cells (TICs) in BRCA samples.
resultsA total of 486 DEGs were identified. These genes were mainly enriched in immune-related pathways. Crossover genes between the hub genes and the prognostic genes were CD2 and CD40LG. CD40LG was further investigated in this study. CD40LG was downregulated in BRCA samples compared with normal samples, and a lower CD40LG expression was associated with advanced tumor stages and a poor prognosis. CD40LG was shown to be involved in immune-related pathways of BRCA by Gene Set Enrichment Analysis. Finally, 14 TICs were found to have a close relationship with CD40LG.
conclusionCD40LG was found to be a core prognostic gene related to tumor microenvironment and deeply involved in immune-related pathways in BRCA. Our findings may provide new insights for exploring the molecular mechanisms of BRCA and developing new immunotherapies for the disease.
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