Evidence map›Paper›PMID 34857976›Full record

ArticleJournal of statistical computation and simulation2021

Using the potential outcome framework to estimate optimal sample size for cluster randomized trials: a simulation-based algorithm.

Ruoshui Zhai, Roee Gutman

Abstract read
In one paragraph

Article in Journal of statistical computation and simulation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ruoshui ZhaiDepartment of Biostatistics, School of Public Health, Brown University, Providence, RI, USA.ORCID 0000-0001-9100-467X
Roee GutmanDepartment of Biostatistics, School of Public Health, Brown University, Providence, RI, USA.

Funding

PROVEN: PRagmatic trial Of Video Education in Nursing homesUH3AG049619 · NIA · BROWN UNIVERSITY · PI MITCHELL, SUSAN L, MOR, VINCENT · 2015 to 2018
$6.2M
NIA NIH HHS UH3 AG049619
6 · The paper itself

Abstract

In cluster randomized trials (CRTs) groups rather than individuals are randomized to different interventions. Individuals' responses within clusters are commonly more similar than those across clusters. This dependency introduces complexity when calculating the number of clusters required to reach a specified statistical power for nominal significance levels and effect sizes. Current CRTs' sample size estimation approaches rely on asymptotic-based formulae or Monte Carlo methods. We propose a new Monte Carlo procedure which is based on the potential outcomes framework. By explicitly defining the causal estimand, the data generating, the sampling, and the treatment assignment mechanisms, this procedure allows for sample size calculations in a broad range of study designs including sample size calculations in finite and infinite populations. It can also address financial and administrative considerations by allowing for unequal allocation of clusters. The R package

Indexed as

causal estimandcluster randomized trialspotential outcomes frameworksample size estimation

Identifiers

PMID34857976
PMCPMC8635296

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.