ArticleNature chemical biology2022
Apoptolidin family glycomacrolides target leukemia through inhibition of ATP synthase.
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Article in Nature chemical biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23citing papers in PubMed
3.7field-weighted citation impact, top 5% of its field
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Who cites it
23 citing papers in PubMed, 49 citations in OpenAlex.
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Authors and funding
12 authors at 3 institutions in 2 countries.
Benjamin J ReismanDepartment of Chemistry, Vanderbilt University, Nashville, TN, USA.
Hui GuoMolecular Medicine Program, The Hospital for Sick Children, Toronto, Ontario, Canada.
Haley E RamseyDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Madison T WrightDepartment of Chemistry, Vanderbilt University, Nashville, TN, USA.
Bradley I ReinfeldMedical Scientist Training Program, Vanderbilt University, Nashville, TN, USA.
P Brent FerrellDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0003-1140-9154
Gary A SulikowskiDepartment of Chemistry, Vanderbilt University, Nashville, TN, USA.
W Kimryn RathmellDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Michael R SavonaDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Lars PlateDepartment of Chemistry, Vanderbilt University, Nashville, TN, USA.
John L RubinsteinMolecular Medicine Program, The Hospital for Sick Children, Toronto, Ontario, Canada.
Brian O BachmannDepartment of Chemistry, Vanderbilt University, Nashville, TN, USA. brian.bachmann@vanderbilt.edu.ORCID http://orcid.org/0000-0001-5815-1176
Vanderbilt University · USUniversity of Toronto · CAVanderbilt University Medical Center · US
Funding
Tumor Immunology and Microenvironment Research ProgramP30CA068485 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI STACIE B DUSETZINA · 1995 to 2026
$172.8MVANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7MVanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ALVIN C POWERS · 2012 to 2026
$29.3MMEDICAL SCIENTIST TRAINING PROGRAMT32GM007347 · NIGMS · VANDERBILT UNIVERSITY · PI WILLIAMS, CHRISTOPHER S. · 1985 to 2023
$26.3MChemistry-Biology Interface Training GrantT32GM065086 · NIGMS · VANDERBILT UNIVERSITY · PI BACHMANN, BRIAN O, SULIKOWSKI, GARY ALLEN · 2002 to 2022
$7.0MSingle Cell Methods for Bioeffector Discovery and AnalysisR01CA226833 · NCI · VANDERBILT UNIVERSITY · PI BRIAN O BACHMANN, Jonathan Michael Irish · 2019 to 2026
$6.1MMedical Scientist Training ProgramT32GM152284 · NIGMS · VANDERBILT UNIVERSITY · PI Christopher S. Williams · 2024 to 2026
$4.8MCoordination of chaperone interactions that dictate protein folding and traffickingR35GM133552 · NIGMS · VANDERBILT UNIVERSITY · PI Lars Plate · 2019 to 2026
$3.2MNew Methodologies for Accelerating Natural Product DiscoveryR01GM092218 · NIGMS · VANDERBILT UNIVERSITY · PI BACHMANN, BRIAN O, MCLEAN, JOHN ALAN · 2010 to 2018
$2.8MVanderbilt Chemical Biology Interface Training ProgramT32GM149371 · NIGMS · VANDERBILT UNIVERSITY · PI Lars Plate · 2023 to 2026
$1.7MInvestigating the role of the JAK/STAT3 Pathway in Clonal Proliferation and Immune Dysfunction in Myelodysplastic SyndromeK23HL138291 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI FERRELL, PAUL B · 2017 to 2021
$817kACQUISITION OF A 500 MHZ LC-NMR: PEPTIDE CHEMISTRYS10RR019022 · NCRR · VANDERBILT UNIVERSITY · PI RIZZO, CARMELO J · 2005 to 2005
$500kCIHR PJT162186NCI NIH HHS F30 CA236131NCI NIH HHS F30 CA247202NCI NIH HHS P30 CA068485NCI NIH HHS R01 CA226833NCRR NIH HHS S10 RR019022NCRR NIH HHS UL1 RR024975NHLBI NIH HHS K23 HL138291NHLBI NIH HHS L30 HL139435NIDDK NIH HHS P30 DK020593NIGMS NIH HHS R01 GM092218NIGMS NIH HHS R35 GM133552NIGMS NIH HHS T32 GM007347NIGMS NIH HHS T32 GM065086NIGMS NIH HHS T32 GM149371NIGMS NIH HHS T32 GM152284
Abstract
Cancer cells have long been recognized to exhibit unique bioenergetic requirements. The apoptolidin family of glycomacrolides are distinguished by their selective cytotoxicity towards oncogene-transformed cells, yet their molecular mechanism remains uncertain. We used photoaffinity analogs of the apoptolidins to identify the F
Indexed as
LeukemiaNeoplasmsAdenosine TriphosphateHumansMacrolidesMitochondrial Proton-Translocating ATPasesAdenosine TriphosphateapoptolidinMacrolidesMitochondrial Proton-Translocating ATPases
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