Evidence map›Paper›PMID 34857911›Full record

ArticleNature materials2022

Engineering living and regenerative fungal-bacterial biocomposite structures.

Ross M McBee, Matt Lucht, Nikita Mukhitov, Miles Richardson, Tarun Srinivasan, Dechuan Meng, Haorong Chen, Andrew Kaufman, Max Reitman, Christian Munck and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature materials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Artificial Symbiosis for Bulk Production of Bacterial Cellulose Composites.Advanced materials (Deerfield Beach, Fla.) · 2026
    Article
  11. Article
  12. Article
  13. Probiotic-Based Materials as Living Therapeutics.Advanced materials (Deerfield Beach, Fla.) · 2026
    Review
  14. Article
  15. Review
  16. Shifu-Inspired Fungal Paper Yarns.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  17. Establishing microbial communities to promote the growth ofApplied and environmental microbiology · 2025
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ross M McBeeDepartment of Biological Sciences, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0003-1926-2863
Matt LuchtEcovative Design, Green Island, NY, USA.
Nikita MukhitovDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-4654-3388
Miles RichardsonDepartment of Systems Biology, Columbia University, New York, NY, USA.
Tarun SrinivasanDepartment of Biological Sciences, Columbia University, New York, NY, USA.
Dechuan MengDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Haorong ChenDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Andrew KaufmanDepartment of Systems Biology, Columbia University, New York, NY, USA.
Max ReitmanEcovative Design, Green Island, NY, USA.
Christian MunckDepartment of Systems Biology, Columbia University, New York, NY, USA.
Damen SchaakEcovative Design, Green Island, NY, USA. damen@ecovativedesign.com.ORCID http://orcid.org/0000-0003-1861-5698
Christopher VoigtDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.ORCID http://orcid.org/0000-0003-0844-4776
Harris H WangDepartment of Systems Biology, Columbia University, New York, NY, USA. hw2429@columbia.edu.ORCID http://orcid.org/0000-0003-2164-4318

Funding

Micron-scale Spatial Metagenomic Mapping of Microbial Biogeography in the Gastrointestinal TractR01AI132403 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Harris H Wang · 2017 to 2026
$6.0M
Ecological dynamics and metabolic interactions in thegut microbiome across space and timeR01DK118044 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI VITKUP, DENNIS, WANG, HARRIS H · 2018 to 2022
$3.4M
NIAID NIH HHS R01 AI132403NIDDK NIH HHS R01 DK118044
6 · The paper itself

Abstract

Engineered living materials could have the capacity to self-repair and self-replicate, sense local and distant disturbances in their environment, and respond with functionalities for reporting, actuation or remediation. However, few engineered living materials are capable of both responsivity and use in macroscopic structures. Here we describe the development, characterization and engineering of a fungal-bacterial biocomposite grown on lignocellulosic feedstocks that can form mouldable, foldable and regenerative living structures. We have developed strategies to make human-scale biocomposite structures using mould-based and origami-inspired growth and assembly paradigms. Microbiome profiling of the biocomposite over multiple generations enabled the identification of a dominant bacterial component, Pantoea agglomerans, which was further isolated and developed into a new chassis. We introduced engineered P. agglomerans into native feedstocks to yield living blocks with new biosynthetic and sensing-reporting capabilities. Bioprospecting the native microbiota to develop engineerable chassis constitutes an important strategy to facilitate the development of living biomaterials with new properties and functionalities.

Indexed as

PantoeaBiocompatible MaterialsHumansBiocompatible Materials

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.