Evidence map›Paper›PMID 34857879›Full record

ArticleCommunications biology2021

NEIL1 and NEIL2 DNA glycosylases modulate anxiety and learning in a cooperative manner in mice.

Gunn A Hildrestrand, Veslemøy Rolseth, Nicolas Kunath, Rajikala Suganthan, Vidar Jensen, Anna M Bugaj, Marion S Fernandez-Berrocal, Sunniva B Sikko, Susanne Vetlesen, Anna Kuśnierczyk and 14 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 4 institutions in 1 country.

Gunn A Hildrestrand *Department of Microbiology, Oslo University Hospital and University of Oslo, N-0424, Oslo, Norway.ORCID http://orcid.org/0000-0003-3160-7203
Veslemøy Rolseth *Department of Microbiology, Oslo University Hospital and University of Oslo, N-0424, Oslo, Norway.ORCID http://orcid.org/0000-0002-6240-7944
Nicolas Kunath *Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology, N-7491, Trondheim, Norway.ORCID http://orcid.org/0000-0002-7641-511X
Rajikala SuganthanDepartment of Microbiology, Oslo University Hospital and University of Oslo, N-0424, Oslo, Norway.
Vidar JensenGliaLab, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, N-0317, Oslo, Norway.
Anna M BugajDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology, N-7491, Trondheim, Norway.
Marion S Fernandez-BerrocalDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology, N-7491, Trondheim, Norway.ORCID http://orcid.org/0000-0002-5839-9355
Sunniva B SikkoDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology, N-7491, Trondheim, Norway.ORCID http://orcid.org/0000-0003-3447-7117
Susanne VetlesenDepartment of Microbiology, Oslo University Hospital and University of Oslo, N-0424, Oslo, Norway.
Anna KuśnierczykProteomics and Modomics Experimental Core Facility (PROMEC), Norwegian University of Science and Technology, N-7491, Trondheim, Norway.ORCID http://orcid.org/0000-0003-3517-3481
Ann-Karin OlsenDepartment of Molecular Biology, National Institute of Public Health, N-0456, Oslo, Norway.ORCID http://orcid.org/0000-0003-3982-5213
Kristine B GützkowDepartment of Molecular Biology, National Institute of Public Health, N-0456, Oslo, Norway.
Alexander D RoweDepartment of Microbiology, Oslo University Hospital and University of Oslo, N-0424, Oslo, Norway.
Wei WangDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology, N-7491, Trondheim, Norway.
Olve MoldestadLaboratory of Cellular Neurophysiology and Ion Channel Function, Department of Molecular Medicine, Institute of Basic Medical Sciences, University of Oslo, N-0317, Oslo, Norway.
Monica D SyrstadDepartment of Microbiology, Oslo University Hospital and University of Oslo, N-0424, Oslo, Norway.
Geir SlupphaugProteomics and Modomics Experimental Core Facility (PROMEC), Norwegian University of Science and Technology, N-7491, Trondheim, Norway.
Lars EideDepartment of Medical Biochemistry, Oslo University Hospital and University of Oslo, N-0424, Oslo, Norway.ORCID http://orcid.org/0000-0003-3948-5183
Arne KlunglandDepartment of Microbiology, Oslo University Hospital and University of Oslo, N-0424, Oslo, Norway.ORCID http://orcid.org/0000-0001-7274-3661
Pål SætromDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology, N-7491, Trondheim, Norway.ORCID http://orcid.org/0000-0001-8142-7441
Luisa LunaDepartment of Microbiology, Oslo University Hospital and University of Oslo, N-0424, Oslo, Norway.
Jing YeDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology, N-7491, Trondheim, Norway.ORCID http://orcid.org/0000-0002-6364-4124
Katja SchefflerDepartment of Clinical and Molecular Medicine, Norwegian University of Science and Technology, N-7491, Trondheim, Norway.
Magnar BjøråsDepartment of Microbiology, Oslo University Hospital and University of Oslo, N-0424, Oslo, Norway. magnar.bjoras@ntnu.no.ORCID http://orcid.org/0000-0001-8759-1170
Oslo University Hospital · NONorwegian University of Science and Technology · NONational Institute of Occupational Health · NOUniversity of Oslo · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oxidative DNA damage in the brain has been implicated in neurodegeneration and cognitive decline. DNA glycosylases initiate base excision repair (BER), the main pathway for oxidative DNA base lesion repair. NEIL1 and NEIL3 DNA glycosylases affect cognition in mice, while the role of NEIL2 remains unclear. Here, we investigate the impact of NEIL2 and its potential overlap with NEIL1 on behavior in knockout mouse models. Neil1

Indexed as

LearningAnimalsAnxietyDNA GlycosylasesGene Expression RegulationHippocampusMaleMiceMice, KnockoutOxidative StressDNA GlycosylasesNeil1 protein, mouseNeil2 protein, mouse

Identifiers

PMID34857879
PMCPMC8639745
OpenAlexW3215797719

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.