Evidence map›Paper›PMID 34857871›Full record

ArticleScientific reports2021

Genomics and transcriptomics landscapes associated to changes in insulin sensitivity in response to endurance exercise training.

Louise Y Takeshita, Peter K Davidsen, John M Herbert, Philipp Antczak, Matthijs K C Hesselink, Patrick Schrauwen, S John Weisnagel, Jeremy M Robbins, Robert E Gerszten, Sujoy Ghosh and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 8 institutions in 6 countries.

Louise Y Takeshita *Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Crown Street, Liverpool, L69 7ZB, UK.
Peter K Davidsen *Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Crown Street, Liverpool, L69 7ZB, UK.
John M HerbertInstitute of Systems, Molecular and Integrative Biology, University of Liverpool, Crown Street, Liverpool, L69 7ZB, UK.
Philipp AntczakInstitute of Systems, Molecular and Integrative Biology, University of Liverpool, Crown Street, Liverpool, L69 7ZB, UK.
Matthijs K C HesselinkDepartment of Nutrition and Movement Sciences, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Centre, Maastricht, The Netherlands.
Patrick SchrauwenDepartment of Nutrition and Movement Sciences, NUTRIM School for Nutrition and Translational Research in Metabolism, Maastricht University Centre, Maastricht, The Netherlands.
S John WeisnagelDiabetes Research Unit, Endocrinology and Nephrology Axis, CRCHU de Québec, Université Laval, Québec City, Canada.
Jeremy M RobbinsDivision of Cardiovascular Medicine, and Cardiovascular Research Center, Beth Israel Deaconess Medical Center, Boston, MA, 02215, USA.
Robert E GersztenDivision of Cardiovascular Medicine, and Cardiovascular Research Center, Beth Israel Deaconess Medical Center, Boston, MA, 02215, USA.
Sujoy GhoshCentre for Computational Biology and Program in Cardiovascular and Metabolic Disorders, Duke-NUS Medical School, Singapore, Singapore.
Mark A SarzynskiDepartment of Exercise Science, Arnold School of Public Health, University of South Carolina, Columbia, SC, USA.
Claude BouchardHuman Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA.
Francesco FalcianiInstitute of Systems, Molecular and Integrative Biology, University of Liverpool, Crown Street, Liverpool, L69 7ZB, UK. falcianf@liverpool.ac.uk.
University of Liverpool · GBBeth Israel Deaconess Medical Center · USMaastricht University · NLDuke-NUS Medical School · SGPennington Biomedical Research Center · USUniversité Laval · CAUniversity Hospital Cologne · DEUniversity of South Carolina · US

Funding

Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI Leigh Lamonica · 2012 to 2026
$69.1M
South Carolina IDeA Networks of Biomedical Research (SC INBRE V)P20GM103499 · NIGMS · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI EDIE C GOLDSMITH · 2012 to 2026
$61.0M
HERITAGE STUDY: GENETICS, EXERCISE &RISK FACTORSR01HL045670 · NHLBI · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI RANKINEN, TUOMO · 1992 to 2010
$6.8M
Transgenics CoreP30GM118430 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI GETTYS, THOMAS W · 2016 to 2020
$5.8M
Molecular Basis of Exercise-induced Changes in HDL FunctionR01HL146462 · NHLBI · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI SARZYNSKI, MARK ANDREW · 2019 to 2023
$3.6M
HERITAGE STUDY: GENETICS, EXERCISE &RISK FACTORSR01HL047317 · NHLBI · WASHINGTON UNIVERSITY · PI RAO, DABEERU C · 1992 to 2003
$1.8M
HERITAGE STUDY: GENETICS, EXERCISE &RISK FACTORSR01HL047327 · NHLBI · INDIANA UNIVERSITY BLOOMINGTON · PI SKINNER, JAMES STANFORD · 1992 to 2003
$106k
HERITAGE STUDY: GENETICS, RESP. TO EXERCISE/RISK FACTORSR01HL047323 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI LEON, ARTHUR S · 1992 to 2003
$100k
NHLBI NIH HHS R01 HL045670NHLBI NIH HHS R01 HL047317NHLBI NIH HHS R01 HL047323NHLBI NIH HHS R01 HL047327NHLBI NIH HHS R01 HL146462NIGMS NIH HHS P20 GM103499NIGMS NIH HHS P30 GM118430NIGMS NIH HHS U54 GM104940
6 · The paper itself

Abstract

Despite good adherence to supervised endurance exercise training (EET), some individuals experience no or little improvement in peripheral insulin sensitivity. The genetic and molecular mechanisms underlying this phenomenon are currently not understood. By investigating genome-wide variants associated with baseline and exercise-induced changes (∆) in insulin sensitivity index (S

Indexed as

Endurance TrainingGenome-Wide Association StudyAdultCalcium SignalingChemokinesFemaleGenetic VariationHealthy VolunteersHumansInsulin ResistanceMaleMEF2 Transcription FactorsMiddle AgedPhysical EnduranceTranscriptomeYoung AdultChemokinesMEF2A protein, humanMEF2 Transcription Factors

Identifiers

PMID34857871
PMCPMC8639975
OpenAlexW3217223379

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.