ArticleScientific reports2021
Optimization of entrapment efficiency and release of clindamycin in microsponge based gel.
Article in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 33 citations in OpenAlex.
- Design-ExpertPharmaceutics · 2026Article
- Brinzolamide microsponge-loaded in situ gel for sustained ocular delivery: design, characterization and in vivo evaluation.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Enhancing skin residence time of penciclovir for the treatment of cold sores: formulation and characterization of controlled release microsponges.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Formulation and Evaluation of Capecitabine-Loaded Microsponges for Colon Targeting.Current drug delivery · 2026Article
- Synthesis of polymer-clindamycin conjugates through lipase-catalyzed esterification and RAFT polymerization.Polymer · 2025Article
- Formulation and Evaluation of Microsponges-loaded Transdermal Gel for the Management of Osteoarthritis.Recent advances in inflammation & allergy drug discovery · 2025Article
- Topical delivery of meropenem via spanlastic carbopol gel:Frontiers in pharmacology · 2025Article
- Multidimensional opioid abuse deterrence using a nanoparticle-polymer hybrid formulation.Journal of controlled release : official journal of the Controlled Release Society · 2024Article
- Targeted Clindamycin Delivery Systems: Promising Options for Preventing and Treating Bacterial Infections Using Biomaterials.International journal of molecular sciences · 2024Review
- Key Fabrications of Chitosan Nanoparticles for Effective Drug Delivery Using Flow Chemistry Reactors.International journal of nanomedicine · 2023Article
- Understanding the Effects of Associated Factors in the Development of Microsponge-Based Drug Delivery: a Statistical Quality by Design (QbD) Approach Towards Optimization.AAPS PharmSciTech · 2022Article
- Microsponge based gel as a simple and valuable strategy for formulating and releasing Tazarotene in a controlled manner.Scientific reports · 2022Article
- Ammonio Methacrylate Copolymer (Type B)-Diltiazem Interactions in Solid Dispersions andPolymers · 2022Article
- Microscale Delivery Systems for Hydrophilic Active Ingredients in Functional Consumer Goods.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnologyReview
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the present study was to formulate clindamycin (CLN) as a microsponge based gel to release the drug in a controlled manner and reduce the side effects in the treatment of acne. Since this method requires poor water solubility of the drug to be loaded in particles, therefore, conversion of the hydrochloride salt to free base was done. By using an emulsion solvent diffusion method, we made six different formulations of microsponges containing CLN-free base by changing the proportions of polymer, emulsifier and the pH of the external phase. These formulations were studied for physical characterization and for drug- polymer interactions. The physical characterization showed that microsponge formulations coded by C5, C6 resulted in a better loading efficiency and production yield and their particle size was less than 30 µm. Scanning electron microscopy images showed the microsponges porous and spherical. C5, C6 microsponge formulation was prepared as gel in Carbopol and in vitro evaluated. The microsponge formulation gel C8 was found to be optimized. C8 released 90.38% of drug over 12 h and showed viscosity 20,157 ± 38 cp, pH of 6.3 ± 0.09 and drug content of 99.64 ± 0.04%. Fourier transform infrared spectroscopy and differential scanning calorimetry confirmed no significant interactions between excipients and drug.
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