Evidence map›Paper›PMID 34857656›Full record

ReviewJournal of nuclear medicine : official publication, Society of Nuclear Medicine2022

Follicular Lymphoma Treated with First-Line Immunochemotherapy: A Review of PET/CT in Patients Who Did Not Achieve a Complete Metabolic Response in the GALLIUM Study.

Sally F Barrington, Farheen Mir, Tarec Christoffer El-Galaly, Andrea Knapp, Tina G Nielsen, Denis Sahin, Michael Wenger, Lale Kostakoglu, Judith Trotman, Michel Meignan

Registry-linked trialAbstract readReview
In one paragraph

Review in Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01332968 (A Multicenter, Phase III, Open-Label, Randomized Study in Previously Untreated Patients With Advanced Indolent Non-Hodgkin's Lymphoma Evaluating the Benefit of GA101), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01332968 phase3completednot on this map

A Multicenter, Phase III, Open-Label, Randomized Study in Previously Untreated Patients With Advanced Indolent Non-Hodgkin's Lymphoma Evaluating the Benefit of GA101 (RO5072759) Plus Chemotherapy Compared With Rituximab Plus Chemotherapy Followed by GA101 or Rituximab Maintenance Therapy in Responders

TypeinterventionalSponsorHoffmann-La RocheRan2011 to 2021Enrolled1,401ConditionsNon-Hodgkin's LymphomaArmsObinutuzumab, Cyclophosphamide, Doxorubicin, Vincristine, Prednisone
3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Analysis of Positive Results ofDiagnostics (Basel, Switzerland) · 2023
    Article
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sally F BarringtonSchool of Biomedical Engineering and Imaging Sciences, King's College London and Guy's and St. Thomas' PET Centre, King's College London, King's Health Partners, London, United Kingdom; sally.barrington@kcl.ac.uk.
Farheen MirDepartment of Haematology, Royal Marsden NHS Foundation Trust, London, United Kingdom.
Tarec Christoffer El-GalalyDepartment of Hematology, Aalborg University Hospital, Aalborg, Denmark.
Andrea KnappProduct Development Oncology, F. Hoffmann-La Roche Ltd., Basel, Switzerland.
Tina G NielsenProduct Development Oncology, F. Hoffmann-La Roche Ltd., Basel, Switzerland.
Denis SahinProduct Development Oncology, F. Hoffmann-La Roche Ltd., Basel, Switzerland.
Michael WengerPharma Development Oncology, Genentech Inc., South San Francisco, California.
Lale KostakogluDepartment of Radiology and Medical Imaging, University of Virginia, Charlottesville, Virginia.
Judith TrotmanHematology Department, Concord Repatriation General Hospital, University of Sydney, Concord, New South Wales, Australia; and.
Michel MeignanLYSA Imaging, Hôpitaux Universitaires Henri Mondor and Université Paris-Est Créteil, Créteil, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Complete metabolic response (CMR) on PET/CT was the sole independent predictor of overall survival in the PET substudy of the phase III GALLIUM trial (NCT01332968) in first-line treatment of high-tumor-burden follicular lymphoma. The aim of this analysis was to further investigate the outcome of patients not achieving CMR.

Indexed as

GalliumLymphoma, FollicularFluorodeoxyglucose F18HumansPositron Emission Tomography Computed TomographyPrognosisProgression-Free SurvivalRetrospective StudiesFluorodeoxyglucose F18Galliumfollicular lymphomaPETresponse assessment

Identifiers

PMID34857656
PMCPMC9364340

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.